Viruses Flashcards
Define the baltimore classification
its the amount of steps needed for a certain virus to produce RNA
What are the 4 main types
0 step
1 step
2 step
3 step
what are 0 step Viruses
DsDNA
DsRNA
ssRNA -
What are 1 step Viruses
ssDNA
ssRNA +
What are 2 step Viruses
ssRNA RT
What is the 3 step virus
DsRNA RT
Give an example of DsDNA
HSV 1
Give an example of a ssDNA
Parovirus
Give an example of DsRNA
Rotavirus
Give an example of ssRNA +
Sars Cov 2
Give an example of ssRNA
Rabies
Give an example of ssRNA RT
HIV
Give an example of DsRNA RT
HBV
What does HIV stand for
Human immunodeficiency Virus
What does HIV target
targets CD4+T helper cells
What effect does it have
kills and destroys CD4+T helper cells leading to increased susceptibility towards new infections
Define a HIV / Virus cell cycle
HIV binds to CD4 Receptor + CCR5 co receptor
Virus fuses with the membrane
uncoats and viral RNA enters the Host cell
DNA transcribed
enters nucleus integrating into the host genome
new viral RNA transcribed
new viral proteins produced
assembles at the membrane
budding leads to generation of mature viral particle released from cell
How is HIV transmitted
Blood
Mucous
What routes can HIV take
Sex
Mother
NEedle sharing
Blood transfusion
What is Anti retroviral therapy (ART)
Treatment for HIV
What is the combination of drugs used for art
2x nucleoside or tide inhibitor
1x integrase inhibitor / boosted protease inhibitor
What is the combination of drugs used for art in pregnancy
2x nucleoside / tide
Give an example of a NNRTI
Tenofovir fumarate
emtricitibane
Give an example of a boosted protease inhibitor
Darunavir
Give an example of integrase inhibitor
Raltegravir
Define prep
pre exposure prophylaxis
- Truvada
Define PEP
Post exposure prohpylaxis
Trevuda
Raltegravir
(4 weeks)
