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PM3A > fungal > Flashcards

fungal Flashcards

1
Q

what fungus

A

single or multicellular organism which can be pathogenic

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2
Q

describe the difference in a fungal cell vs human cell membrane

A

cell wall made up of
manoproteins
b 1 -3 glucan
b 1 -6 glucans

in membrane
ergosterol
b 1 -3 glucan synthase

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3
Q

what the main antifungal drugs

A

polyenes
azoles
allylamines
echinocandins
flucytosine

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4
Q

describe the routes of polyenes and their toxicitys

A

oral - non toxic
iv - very toxic use for life threat

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5
Q

describe the spectrum of the polyene

A

broad

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6
Q

give an example of polyene

A

amphotericin B

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7
Q

MOA polyene

A

bind to egosterol in membrane forming pore
leak of K+ / Mg2+
causing cell death

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8
Q

what type of antifungal is polyene

A

fungicidal

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9
Q

What are 2 types of azoles

A

imidazole
triazoles

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10
Q

describe the spectrum of the 2 azoles

A

imidazole - dermatophytes, candidiasis

triazoles - broad

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11
Q

describe the route of the 2 azoles

A

imidazole - topical

triazole - depends on infection

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12
Q

describe azole moa

A

inhibit lanosterol 14 alpha demethylaze
interfering with ergosterol biosynthesis
disrupts plasma membrane

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13
Q

what type of antifungal is an azole

A

fungistatic

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14
Q

describe the spectrum of allyamine

A

mainly dermatophytes, nail infections and ringworm

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15
Q

describe the moa of allyamine

A

inhibits squalene epoxidase
preventing formation of lanosterol
stopping the formation of ergosterol

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16
Q

what the of antifungal is allyamine

A

fungistatic

17
Q

describe the spectrum of echinocandins

A

broad often being used for serious systemic infections

18
Q

describe the moa of echinocandin

A

inhibit the production of b1-3 glucan via b glucan synthase

19
Q

what type of antifungal is echinocandin

A

fungicidal

20
Q

what is the route of flucytosine

A

orla or iv

21
Q

what is the spectrum of flucytosine

A

used in combination with other drugs for

severe cryptococcal or candida system infection

22
Q

what is the moa of flucytosine

A

converted into 5 FU where disrupts RNA / DNA syntehsis

23
Q

what type of antifungal is flucytosine

A

fungistatic

24
Q

what is the treatment for candidiasis

A

azole , polyenes

25
Q

what is the treatment for vulvovaginal candidiasis

A

fluconazole

26
Q

what is the treatment for candidiasis of nail

A

topical use of amorolfine for 6months

27
Q

what is the treatment of dermatophytosis

A

head - griseofulvin or terbinafine
skin - topical imidazoles
nails - amorolfine for 6 months

28
Q

what is the treatment of aspergillosis

A

voriconazole

29
Q

what us the treatment of pityriasis

A

antifungal creams e.g. fluconazole

PM3A (4 decks)

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