Virus Structure and Function Flashcards

1
Q

Virion

Do they undergo division?

A

infectious, mature viral particle

• Do not grow or undergo division
- replicates using host machinery

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2
Q

Describe two means of classifying viruses.

A

The Classical System

The Baltimore System

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3
Q

The Classical System

A

Grouping by shared physical properties

  • Nature of the genetic material (is it DNA or RNA?)
  • Symmetry of the capsid (is it helical or icosahedral?)
  • Naked or enveloped
  • Dimensions of the virion and capsid
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4
Q

The Baltimore System

A

Based upon how they produce mRNA (The Central Dogma)

+ mRNA is the ribosome ready component

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5
Q

What type of genome is always in icosahedral capsids?

A

Q

Genome is always RNA

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6
Q

Do viruses with Helical or Icosahedral capsids have envelopes?

A

Almost all helical-packaged capsules in animal viruses have envelopes

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7
Q

Where on the virus are glycoproteins found?

A

viral glycoproteins embedded in the envelope membrane

there are proteins on the capsid as well

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8
Q

Which virus replicate in the cytoplasm? How?

A

Poxvirus (a dsDNA) - brings its own RNA pol to the party

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9
Q

Two periods/phases of viral replication cycle

A

Eclipse period

Latent period

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10
Q

What do viruses attach to when trying to infect? Which is more specific?

A

On the host membrane

  • Protein receptors or
  • Carbohydrate receptors (less specific)

• Virus will attach to anything it can attach to - no strict “rules” of which virus attaches to which receptor
- the receptor dictates the susceptibility or resistance of the cell

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11
Q

What is significant about entry of a virus? Why is this important?

A

• This is an energy-dependent process
Body will adapt when infected:
- shunt energy towards defense
- be less metabolically active

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12
Q

Does endosome formation with a virus apply to ones with or without envelopes?

A

Both can form endosomes

*but viruses with envelopes can fuse instead of forming an envelope

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13
Q

How are the goals of viral gene expression different from genome replication?

A

gene expression: goal is to make proteins

genome replication: goal is to replicate viral genetic material (many diff ways)

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14
Q

How is assembly of iscosahedral capsids diff than helical nucleocapsids?

A

Q

For icosahedral capsids packaging of the genome in one of 2 ways:

○ Capsid assembles around the virus genome or
○ Genome is “fed” into preformed capsids
For helical nucleocapsids viral genome is coated with nucleocapsid protein DURING synthesis of the genome

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15
Q

Diff types of Egress

A
  • “Naked” capsids are released from cells by lysis

* Enveloped capsids egress by budding

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