Virus SSTI Flashcards
Papillomas Nodules
Warts
Molluscum
Warts
HPV
Papovaviridae family
Molluscum Contagiosum
Molluscum Contagiosum Virus
Poxyviridae family
Ulcers and purulent lesions
Herpes labialis
Chicken pox
Herpes zoster/ shingles
Small pox
Cold sores
Herpes labialis
Herpes simplex virus
Herpesviridae family
Chicken pox
Varicella zoster virus
Herpesviridae family
Herpes Zoster
Shingles
VZV reactivation
Herpesviridae family
Small pox
Variola virus
Poxiviridae family
Childhood rash & fever
Measles
German measles
Fifth disease / Erythema
Roseola infantum
Rubeola
Measles
Measles Virus
Paramyxovirus familly
German Measels
Rubella Virus
Togaviridae
Erythema infectiosum
Fifth Disease
B19 Parvovirus
Parvoviridae
Roseola infantum
HHV 6 & 7
Herpesviridae
HPV
Non enveloped dsDNA
Replication tied to tissue infected
Expansion of epithelial layer
HPV VF
E7 inhibits RB
E6 inhibits p53
100 serotypes
HPV Transmission
Direct contact cut/abraisons
New HPV virions form in
suprabasal layer of skin
HPV symptoms
Warts exophytic
Plantar warts
Punctate hemorrhage
Flat warts mouth
HPV Diagnose and treat
Clinical signts: Hyperkeratosis & Koilodal cells. Cryotherapy Cytotoxic chemical Surgical removal HPV vaccine 16 & 18 not cutaneous
MCV
Large dsDNA
Replicates in cytoplasm
MCV Transmission
Direct contact w/ lesion
STD
On face or genitals
MCV Symptoms
Painless pearly nodules
Central depression purulent fluid
Molluscum bodies
MCV Diagnose & Treat
Signs
Resolves w/ out or
Surgery cryotherapy
HSV
Enveloped dsDNA
Latent n Lytic
HSV 1 oral
HSV 2 genital
HSV Transmission
Direct contact w/ lesion or saliva.
Follows PNS
TGG
HSV Symptoms
- cold sore
- recurrent
Simplex keratitis blindness
Whitlow neonates toes
Encephalitis
HSV Treat
Acyclovir
Varicella zoster virus
Enveloped dsDNA
VZV transmision
Resp secretions
Saliva
Direct contact
VZV Symptoms
Lesion mostly in trunk face and scalp
Vesicle - postules - scabs
Bacterial infection of lesions
Pnuemonia or dissemination
VZV Diagnose & Treat
Signs Serology Vaccine - LIVE ATTENUATED Also helps against SHINGLES Acyclovir
VZV Shingles Symptoms
Paresthesia prodrome
vesicular lesions on trunk
unilateral fever malaise
Postherpetic neuralgia
Variola virus
Large dsDNA
Replicates in cytoplasm
Own enzymes
Strictly human
Variola Transmission
Aerosol
Contact lesion
Contagious until all scabs cleared
Variola symptoms
Abrupt high fever Malaise headache Myalgia nausea Lesion on mouth & skin Centrifugal and On palms and soles Resp tract Encephlitis Hemorrhagic Mortality higher
Variola Diagnose & treat
Vaccine
LIVE ATTENUATED
Eradicated
Measles Virus
Enveloped ssRNA
F gene fusion
HA attachement
Measles Transmission
Resp. shed in nasopharynx
Highly contagious
Infect up to 2 hr in air
Measles symptoms
Cough Coryza Conjunctivitis Kopliks spots Annorhexia, diarrhea otitis media, pneumonia encephalitis seizures and death
Measles diagnose & treat
Immuno prophalaxis
Vaccine
LIVE ATTENUATED
Rubella Virus
Enveloped
+ssRNA
Rubella transmission
Resp
Rubella signs
Maculopapular rash 1st face and the downward
Fainter and don’t coalesce
arthralgia arthritis
Newborns deafness blindness CHD
Rubella diagnose and treat
direct culture rtPCR serology
VACCINE
LIVE ATTENUATED
to prevent congenital syndrome
B19
ssDNA
Grows in mitotic active cells
Uses host
B19 symptoms
Slap cheek
Fever
Rash lacelike
Aplastic chrisis: chronic anemia arthralgia arthritis hydrop fetalis
HHV 6/7
Enveloped dsDNA
HHV 6/7 workings
Prim infect by 3
Replicates in T and B cells
HHV 6/7 signs
High fever 4 days
Maculopapular rash follows
7 - t cell infect later than 6
