Virus Overview

Question 1

Largest known virus

Complex shape

Answer 1

Poxvirus

Question 2

Name the type of virus genome

Herpesviruses:

Answer 2

Linear, nonsegmented, ds-DNA

Question 3

Name the type of virus genome

Papillomaviruses:

Answer 3

circular, nonsegmented ds-DNA

Question 4

Name the type of virus genome

HIV

Answer 4

linear, ssRNA

Question 5

Name the type of virus genome

Rotaviruses:

Answer 5

Linear, segmented ds-RNA

Question 6

Name the type of virus genome

Polio

Answer 6

Linear, ss-RNA

Question 7

Name the type of virus genome

HCV:

Answer 7

Linear ss-RNA

Question 8

Name the type of virus based on its entry:
Binding –> virus enter cells –> internalization into endosomes
Some enter under neutral pH, some under low pH

Answer 8

Naked virus

Question 9

Name the type of virus based on its entry:

Viral glycoprotein binds to one or more cell receptors –> viral uptake

Answer 9

Enveloped virus

Question 10

Viral gp is main source of interaction between ___ viruses and environment

Answer 10

enveloped

Question 11

Capsid is main source of interaction between ___ viruses and environment

Answer 11

naked

Question 12

DNA viruses replicate in the ___

Answer 12

cell nucleus

Question 13

Poxviruses (a DNA virus) replicate in ___ and encode their own ___ and ___

Answer 13

cytoplasm
DDRP
DDDP

Question 14

Name the type of virus that uses this type of genome replication:
Uses RNA genome as mRNA –> directly translated using cellular translation machinery

Answer 14

Positive sense RNA viruses

Question 15

Name the type of virus that uses this type of genome replication:
No need to bring polymerase into infected cell

Answer 15

Positive sense RNA viruses

Question 16

RNA viruses replicate in ___

EXCEPT: (2)

Answer 16

cytoplasm

Hepatitis D virus, orthomyxoviruses (influenza)

Question 17

Name the type of virus that uses this type of genome replication:
___ must be packaged into virions along w/ genome RNA

Answer 17

RDRP

Negative sense RNA viruses

Question 18

Name the type of virus that uses this type of genome replication:
Positive strand RNA –> dsDNA –> integrated into cell DNA –> provirus

Answer 18

retrovirus

Question 19

Most DNA viruses use this approach of viral particle assembly

Answer 19

Capsid self-assemble and genome stuffed in

Question 20

All helical, som icosahedral RNA viruses use this approach of viral particle assembly

Answer 20

Capsid assembles around genome

Question 21

Most non-enveloped viruses egress by ___

Answer 21

destroying the cell = cytolytic viruses

Question 22

Enveloped viruses egress by ___

Answer 22

budding from plasma membrane using ESCRT proteins

Question 23

T/F: All human icosahedral viruses that cause disease and enveloped.

Answer 23

False: all human HELICAL viruses

Question 24

Smallpox, polio, HIV are acquired from

Answer 24

human to human spread

Question 25

Influenza is acquired from

Answer 25

animal reservoirs, human to human spread

Question 26

Dengue fever and yellow fever are acquired from

Answer 26

human reservoirs but NO human human transmission. Need vector (mosquito)

Question 27

West Nile, rabies are acquired from

Answer 27

animal reservoir that infect humans. No human human transmission.

Question 28

Influenza virus is limited to:

Answer 28

respiratory tract

Question 29

Papilloma virus is limited to:

Answer 29

only epithelial cells