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MOHD 4 Exam 2 > Bacteria, Spirochetes, Rickettsia, Mycobacterium > Flashcards

Bacteria, Spirochetes, Rickettsia, Mycobacterium Flashcards

1
Q

Virulence factor of treponemes

A

Attach to endothelial cells and pass through blood vessel walls

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2
Q

Symptoms of ___:
Non tender chancre around infection site after 3-4 weeks
Resolves itself

A

Primary syphilis

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3
Q 
Symptoms of \_\_\_\_:
Fever, sore throat, lymphadenopathy, headache, rash on palm and feet
Highly contagious
Nephrotic syndrome
Condylomata lata
A

Secondary syphilis

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4
Q

Symptoms of ___:
Gummas = nonprogressive granulomatous lesions of dermal elements or support structures
Neurosyphilis
Inflammatory reaction of large vessels of heart

A

Tertiary syphilis

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5
Q

Jarisch-Herxhemier

A

Mild endotoxin shock like syndrome 2-12 hours after PCN treatment
(Treponemes treatment)

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6
Q

Borrelia recurrentis:

Symptoms:

A

Louse borne epidemic illness

4-10 day periods of high fever and hypotension

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7
Q

Borrelia hermisii:

Endemic to:

A

Tick borne illness

Rocky mountain west

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8
Q

Borrelia burgdorferi causes:

Symptoms:

A

Lyme disease: tick borne illness (lxodes ticks)

Migrating erythematous rash, arthritis, myocarditis, neurological disease

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9
Q

Rickettsia
Gram:
Type of bacteria:

A

Negative

Obligate intracellular

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10
Q

Spotted Fever transmission

A

Lxodidae (hard tick) naturally infected w/ Rickettsia

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11
Q

Spotted Fever Pathogenesis
Target cell:
Virulence factor:
Symptoms:

A

Endothelial cell
LPS
5-10 days after bite: Fever, rash, history of tick bite

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12
Q

Ehrlichia
Shape and gram:
Obligate pathogen of ___

A

Gram - cocci

leukocytes

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13
Q

Morulae =

Found in ___ infections

A

Divide to form vacuole bound colonies

Ehrlichia chaffeensis

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14
Q

Ehrilichia infection looks like Rocky Mountain Spotted Fever EXCEPT ___
Symptoms:

A

no rash

Fever, headache, malaise, muscle aches

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15
Q

Mycobacterium properties
Shape and stain:
Type:
Metabolics:

A

Acid fast rods
Facultative intracellular pathogens of PMNs/macrophages
Aerobes

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16
Q

M. leprae is an exception to mycobacterium b/c:

A

it is an obligate intracellular pathogen

17
Q

Ghon complex=

Characteristic of:

A

Tubercles = granuloma

M. tuberculosis

18
Q

Treponeme pallidum causes

A

syphilis

19
Q

Causes acid fastness of mycobacteria

A

Wax D

Virulence factor

20
Q

Cell associated iron chelator

A

Mycobactin

Mycobacteria virulence factor

21
Q

Sulfo-glyco and sulfo-lipids

A

Prevents fusion of phagosome and lysosomes

Virulence factor of mycobacteria

22
Q

Photochromogens:
Ex:

A

Yellow pigmented in light

M. kansasii

23
Q

Scotochromogens:
Ex:

A

Always pigmented but intensify in light

M. scrofulaceum

24
Q

M. avium-intracellular complex

A

Nonpigmented atypical mycobacterium

HIV associated

25
Q

Hospital associated sternal infections, rapid growers, atypical mycobacteria

A

M. fortuitum

26
Q

T/F: Atypical mycobacteria are susceptible to most anti-TB drugs
T/F: Atypical mycobacteria are highly contagious.

A

False. Are resistant

False. Non-contagious

27
Q

Buruli ulcers are characteristic of ____ infection
Caused by:
Treatment:

A

M. ulcerans
nonprotein toxin
Surgical removal + abx

28
Q

Symptoms of indeterminate phase of leprosy

A

Hypo or hyperpigmented lesions

NO sensation loss

29
Q

Symptoms of tuberculoid (Pauci bacillary) phase of leprosy

A

multiple lesions

Peripheral nerve damage w/ loss of sensation

30
Q

Symptoms of lepromatous (multi-bacillary) phase of leprosy

A 
Lots of nerve damage
NO immune response 
Skin thickens, loss of eyebrows and lashes
Destruction of nasal septum 
Blindness
Traumatic tissue loss
31
Q

Lepromatous leprosy patients treated with abx will develop ____ due to ____

A

Erythema nodosum leprosum

Type 3 hypersensitivity

MOHD 4 Exam 2 (4 decks)

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