Virus - Herpes, HIV Flashcards
Blood cell/protein count during acute seroconversion phase of HIV
Causes leukopenia although CD4+ count levels at this stage is still normal
Antibodies appear within 10-14 days of infection with seroconversion (antibody becomes detectable in blood) within 3-4 weeks
Specific symptoms of HSV2
Herpes progenitalis (vesiculoulcerative lesions of the genitalia): painful inguinal lymphadenopathy with clusters of vesicles with red base (vesicular eruptions)
Neonatal herpes: jaundice, hepatosplenomegaly, thrombocytopaenia, large cutaneous vesicles
Symptoms of varicella
- Fever, headache, malaise and abdominal pain
- Childhood exantham: crops of vesicles (later developing into pustules, with neutrophils) in waves
- Centripetal distribution (more on trunk than extremities)
- Appears for 1-7 days
- Vesicles may become pitted scars if scratched, leads to skin superinfection if unclean - Infection during pregnancy
Complications of varicella
- Aseptic meningitis
- Post-infectious encephalomyelitis
- Pneumonia
- Haemorrhagic condition (fulminating varicella) due to thrombocytopenia & disseminated intravascular coagulation
- Arthritis
Symptoms of zoster
Painful vesicular eruption morphologically similar to varicella
Skin distribution corresponds to dermatomal distribution
- Thoracic: 50% (because lesions are usually found on trunk in primary infection)
- Trigeminal nerve: herpes zoster opthalmicus
- Geniculate ganglion: ramsay hunt syndrome (facial paralysis and hearing loss in the affected ear), vesicles in external auditory canal/tympanic membrane
Complications of zoster
- Encephalomyelitis
- Post-herpetic neuralgia (phantom nerve pain after zoster infection)
- Disseminated zoster in the immunosuppressed/elderly → vesicles outside infected dermatome
Where does cytomegalovirus remain latent in
Circulating mononuclear cells (Eg. B and T cells, macrophages)
HHV6 latency
in B cells
symptoms of HHV6
associated with exanthema subitum (viral rash)
