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Question 1

What are the factors involved in gastric mucosal protection against autodigestion - Mucus secretion

Answer 1

acid & pepsin-containing fluid exits gastric glands as jets passing through surface mucus layer without contacting surface epithelial cells

Question 2

What are the factors involved in gastric mucosal protection against autodigestion - Bicarbonate secretion

Answer 2

surface epithelial cells in stomach & duodenum secrete bicarbonate into boundary zone of adherent mucus, creating pH neutral microenvironment adjacent to cell surface

Question 3

What are the factors involved in gastric mucosal protection against autodigestion - Epithelial barrier

Answer 3

intercellular tight junctions provide barrier to back-diffusion of H+ ions

Question 4

What are the factors involved in gastric mucosal protection against autodigestion - Mucosal blood flow

Answer 4

rich blood supply provides oxygen, bicarbonate & nutrients to epithelial cells and removes back-diffused acid