Virology

Question 1

what population is most at risk of developing Chronic HBV

Answer 1

infants with perinatal hep B infections - 90% risk

Question 2

what is the risk of developing HCC or cirrhosis from chronic HBV

Answer 2

25%

Question 3

what are common manifestation of Hep B

Answer 3

LOW PLTs
arthralgia
arthritis
macular rash
acrodermatitis - Gianotti-Crosti syndrome
polyarteritis nodosa
membranous proliferative GN
leukocytoclastic vasculitis.

Question 4

What does HBsAg mean?

Answer 4

Indicates acutely or chronically infected person

Question 5

What does HBsAb mean?

Answer 5

resolution of infection or

after immunization

Question 6

what does HBeAg mean?

Answer 6

Indicates high viral replication and increased infectivity

Question 7

What does HBeAb mean?

Answer 7

Indicates decreased viral reproduction and decreased infectivity

Question 8

what does HBcAb mean

Answer 8

Indicates acute, chronic, or resolved infection

NOT from immunization!!!!

Question 9

What are the criteria for Chronic Hep B status

Answer 9

HBsAg >6 months or

of HBsAg and Neg IgM HBcAb

Question 10

what factors may increase risk of cirrhosis or HCC in Hep patients

Answer 10

race,
genotype of the virus, 
alcohol consumption, 
coinfection with hep A,  C or D, 
coinfection with (HIV)

Question 11

what is the treatement of Chronic HBV

Answer 11

lamivudine PO or
interfeon Alpha 2b SQ, better.

more for pt with high LFT,
Rx for chronic HBV infection (HBsAg positivity for
at least 6 mo) and have had serum alanine aminotransferase greater than 2X for at least 3mo

Question 12

What is the testing required for a baby prenatally exposed to HIV?

Answer 12

HIV PCR done within 48hr, 2 weeks, 2 month, 4-6month

+/- 18 month antibodies

Question 13

what are risk factors for vertical transmission of HIV

Answer 13

high viral load
seroconversion during pregnancy
low mat CD4
preterm
prolonged ROM
SVD
scalp probe