Virology Flashcards
Which RNA virus is double stranded? Which are positive stranded?
- Reovirus
- Retrovirus, togavirus, flavivirus, coronavirus, hepevirus, calcivirus, picornavirus
Which DNA virus is not double stranded? Which are circular?
- parvovirus
- Papilloma, polyoma, hepadna
Where do DNA viruses replicate? Where do RNA viruses replicate? What are the exceptions?
DNA- nucleus except pox, RNA- cytoplasm except influenza and retroviruses
What are characteristics of herpesviruses? Whats the CNS path of HSV-1? Features of EBV? What causes roseola? Kaposi sarcoma?
Enveloped
HSV1-temporal lobe encephalitis (AMS, seizures, aphasia), Tzanck
EBV- infects B cells through CD21, atypical lymphs, tested by heterophile antibodies
HHV-6/7 roseola. HHV8: Kaposi sarcoma
What are characteristics of hepadnavirus?
Enveloped, circular, HBV (has reverse transcriptase
What does adenovirus do?
Febrile pharyngitis, hemorrhagic cystitis, pneumonia, pink eye
What are features of parvovirus? Whats the risk to a fetus?
Single stranded, RBC destruction causes hydrops fetalis
Whats the features of papillomavirus?
Circular
What are polyomavirus characteristics? What diseases do it cause?
JC virus-progressive multifocal leukoencephalopathy
BK-targets kidneys in transplant pts
What are characteristics of poxvirus? What diseases are included?
Enveloped, cowpox and molluscum contagiosum
Characteristics
D
How is HIV diagnosed?
Its ruled out with ELISA, confirned by Western blot assay
What are three structural genes in HIV?
Env (gp120-CD4 attachment and 41-fusion and entry), gag (caspid protein), pol (reverse transcriptase, integrase, aspartase protease)
How does HIV enter cells? How are some people immune?
It binds to CD4 and CCR5 on macrophages (early) and CXCR4 on T cells (late)
-Homozygous CCR5 mutation: immunity
What does HAV IgM mean? igG?
IgM- acute infection
IgG- prior HAV infection or prior vaccination
