Virology

Question 1

How is HSV diagnosed and what is the treatment?

Answer 1

Diagnosed by swab from lesion (PCR)

Aciclovir

Question 2

What are the indications for antiviral treatment with chickenpox and what is the treatment?

Answer 2

Aciclovir

Indications: all adults with chickenpox, neonates, immunocompromised, eye involvement

Post-exposure prophylaxis for pregnant: VZIG

Question 3

What is management for shingles?

Answer 3

Acyclovir if within 72hrs onset or over 50yo

Question 4

What are some complications of varicella zoster virus infection?

Answer 4

Can cause Ramsay-Hunt syndrome and ophthalmic herpes

Question 5

What infection is associated with owls eye inclusions on histology?

Answer 5

Human Cytomegalovirus

Question 6

What cancer is associated with EBV?

Answer 6

Burkitt’s lymphoma

Question 7

Which hepatitis viruses are transmitted via faecal-oral route?

Answer 7

Hep A&E

Question 8

What si the gold-standard for diagnosing Hep B infection?

Answer 8

Serum HBsAg

Chronic infection is persistence of HBsAg > 6 mo

Question 9

What antibody does the HBV vaccine produce?

Answer 9

Anti-HBs

Question 10

How to differentiate acute and chronic Hep B infection?

Answer 10

IgM anti-HBc will be present in acute but not chronic.

Question 11

What does presence of Anti-HBs indicate?

Answer 11

HBV Vaccination or previous cleared infection