Viral resp. disease

Question 1

What are the top three URI-causing viruses?

Answer 1

Rhinovirus (69%), Coronavirus (15%), RSV (1%)

Question 2

How many viruses are there of each subtype?

Answer 2

H (1-14), N (1-9); In humans H (1-3), N (1-2)

Question 3

Antigenic Drift vs shift

Answer 3

Drift-slight changes in H or N antigens which do not change the type of antigen thru random mutations. Shift-Animals serve as pool where reassortment with other flu viruses can occur, changes antigen (eg H1->H2), esp in pigs

Question 4

What do Hemaglutinin and neuramididase do?

Answer 4

H-binding to sialic acid on cell surface. N-cleaves sialic acid so mature virus can be released