Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Neuro > Viral Infections fo the CNS > Flashcards

Viral Infections fo the CNS Flashcards

(81 cards)

Start Studying
1
Q

acute viral meningitis usually

A

mild and self-resolving completely in 7-10 days

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

acute bacterial meningitis

A

life threatening

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

most common cause of meningitis

A

viral

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

predictors of BACTERIAL MENINGITIS

A

LOW CSF GLUCOSE
HIGH PROTEIN
HIGH CSF WBC COUNT
HIGH PMN COUNT

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

patients with viral meningitis present

A

not severely ill looking-not encephalopathic

HA, Low Back Pain, neck stiffness, fever mailaise

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

viral types of meningitis

A

80%-entero (echo, cocksack, entero 71
10% mumps
10% aseptic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

recurrent aseptic meningitis due to

A

HSV2, HIV, VZV

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

viruses causing ecephalitis

A

30%-arborviruses
23%-enteroviruses
27%-HSV1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

treatable with acylovir and causes encephalitis

A

HSV1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

seen in family outbreaks via URI of GI infections-also causes encephalitis

A

enteroviruses

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

encephalitis cause-seen with high seasonality, transmitted by misquitos or ticks-most common in very old and young

A

arborviruses

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

HSV encephalitis more commonly caused by

A

reactivation of latent infections over primary infection

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Diagnostic signs present in HSV encephalitis

A
  1. MRI shows necrosis of temporal lobe,
  2. RBC’s in CSF=necrosis

*HSV tropic for temporal lobe

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

three families of mosquito borne encephalitis viruses

A

Flavaviridae
Togaviridae
Bunyaviridae

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

classificiation features of flavaviridae

A

small, ENVELOPED, non-segmented, +RNA virus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

three genera of family flavaviridae

A

Flavaviruses
Pestiviruses
Hep C

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Main players in Flavavirus genera

A

St. Louis encephalitis
West Nile
Japanese ecephalitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

after endocytosis and fusion related nucleocapsid release–> poly protein made by host ribosomes) is cleaved by viral (cis0cleavage) and host (trans cleavage) poteases

A

flavaviruses

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

all _____ viruses are transmitted by insects and are found thruout the world

A

flavaviruses

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

most important type of arboviruses

A

flavaviruses

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

secondary viremia (flavavirus not contained in spleen or in lymphnodes) what happens

A

secondary viremia can occure and encephalitis can happen

this is a minority of cases

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

3 clinical syndromes occuring with SLE

A

febrile headache
aseptic meningitis
encephalitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

most effective means of control for SLE

A

control mosquito population

there are no effective antivirals or vaccines

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

transmision via Culex species of mosquito

A

west nile virus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
transmission cylce of west nile
culex mosq, takes blood meal from infected birds, virus localizes to salivary gland of mosq, transmission to humans as incidental hosts only 1% will get seriously ill if infected
26
mild WNV
fever, headache skin rash, LAN, mylagia
27
severe WNV infection
severe HA, high fever, neck stiffness, muscle weakness, stupor, tremors, disorientation, sonvulsions tremors, soma paralysis, rarely death
28
tx for WNV
NON-SUPPORTIVE FLUIDS HOSPITALIZATION, CONTROL MOSQUITO POPO
29
JAPANESE ECEPH
IF YOU GOING TO SE ASIA OR INDIA OR USSR FOR OVER ONE MONTH GET VACCINE
30
CLASS CHARACTERS OF TOGAVIRIDAE
small, enveloped, non-segmented, positive sense RNA
31
two genera that make up togaviridae
rubiviruses | alphaviruses
32
only member of rubivirus family
rubella | *limited host range
33
genera in alphaviruses
Western Equine encephalitis, EEE, VEE,
34
raplication for alphaviruses
witt is a fag and says "go look at rubella" wiki has a fucking 90 page thing but the answer will be somehting wih E1 and E2 proteins and the capsid protein having a diff,. fucniton...i dk my bff rose
35
initially replicates in muscle and fibroblasts of various organs
alphaviruses
36
after replicating in muscles and fibroblasts, aslpha viruses sometimes
induce low level viremia within 24 hours, invade CNS-destroy neurons
37
usually fever for 2 weeks--> then encephalitis
alpha viruses
38
after encephalopathy of ALPHA viruses begins..describe clinical course
usually become comatose and die within first few days of hospitalization fever, diziness, LOC
39
enveloped, spherical particles with segmented, ssRNA, negative sense
Bunyaviruses
40
genera of bunyaviruses causing CNS infection (2/5)
California Encephalitis Virus | La Cross Encephalitis Virus
41
genes found on 2-3 separat segments
bunyavirus otherwise replication like other negative sense viruses
42
similar to influenza except replicaiton occurs entirely in the cytoplasm and mRNAs are not spliced
bunyaviridae CEV LCEV
43
most common cause of arboviral pediatric encephalitis in US
La Cross Virus--> bunyaviridae
44
manifest as seizures and focal neurological signs in children mainly
Lacross virus
45
Animal Vector Encphalitis Virses
1. Rhabdoviridae
46
can reassort based on segmentation
bunyaviruses
47
enveloped, nonsegmented, negative sense ssRNA, with bullet shaped morphology
rhabdovirus-RABIES
48
bullet shaped morphology
rabies
49
rahbdo genera that cuase dz in humans
vesiculoviruses | lyssaviruses
50
which one is the rabies im thinking of
lyssvirus rhabdoviridae
51
cell entry hinges on single glycoprotein with pH dependent fusion activity
rhabdoviridae-enter in pH dependent manner otherwise like paramyxoviruses
52
replication of rabies-just like a paramyxovirus
The virions attach to the surface of a host cell, and the envelope fuses to the plasma membrane. The nucleocapsid is released into the cell. The negative-sense RNA is transcribed into individual messenger RNAs and a positive-sense RNA template, which is used to create negative-sense RNA. Assembly occurs, and new viruses bud from the cell membrane (which is how they become enveloped).
53
rabies replication exclusive to ...
neurons-but once it reached brain it goes to other organs
54
during final stages, rabies found in high concentration in the
salivary glands
55
uniformly fatal it post exposure treatment not given
rabies
56
incubation of rabis typically
long 2-3 months can be a week tho
57
after entry/replication in the muscle after a bit, rabies virus
transported through peripheral sensory nerves to spinal ganglia where it replicated and travels up cord to brain
58
rabies tropic for neurons in which parts of the brain
limbic system, midbrain, and hypothalamus
59
early prodromal rabies
mild, nonspecific *caution if itching, burning, numbness around bite locally
60
acute neurological phase of rabies
Nervous system dysfunction anxiety agitation, paralysis, delirium "furious rabies"-agitation predom "dumb rabies" somnolence predom
61
hydrophobia, exaggerated gag reflex to protect airway seen in
rabies-lyssavirus
62
2-7 days after neurologic phase--rabies patients fall into
comadeath from rabies usually due to respiratory depression
63
post exposure prophyllaxis of rabies
clean wound intra-wound introduciton of human-anti rabies Ig and multiple doses of rabies vaccine
64
rabies vaccine is a
inactivated vaccine
65
enveloped, segmented, ambisense RNA virus another animal borne ecephalopathic virus
arenaviridae
66
virus contains 2 rna segments coding for 4 proteins
Lymphocytic choriomeningitis virus LCMV Aerenaviridae
67
member of arenaviridae
LCMV lymphocytic choriomenigitic virus
68
LCMV-arenavirus-non-conventuional ambisense replication strategy--describe this shit
1. genome used as template for transcription and the NP and M MRNAs produced frmo either the long or the short RNA segment polymerase produces full length antigenome for each segment positive sense antigenome is then used as a template for transcription of glycoprotein mRNA assembly and exit
69
can cause sudden onset of deafness in meningeal pahse of dz
LCMV
70
transmitted form rodent excreta and saliva
arenavirus-LCMV
71
HIV can case acute asceptic meningitis at
serovonversion-primary viremia
72
most common opportunistic infection in AIDS pt.s
toxoplasmosis
73
JC virus in HIV can cause
PML progressive multifocal leukodystrophy
74
Mollerate cells in CSF
recurrent HSV2 meningitis
75
HSV1 responds to
acyclovir
76
CMV responds to
GANCICLOVIR
77
WHICH VIRUSES HAVE A POOR PROGNOSIS ONCE ENCEPHALITIS DEVELOPS
LACROSS CALIFORNIA ENCV EEV WEST NILE
78
UNIFORMLY LETHAL IF NOT TREATED
RABIES
79
"NECROSIS IN TEMPORAL LOBE"
HSV1
80
MISQUITO BORN VIRUS FAMILIES
FLAVA ALPHA (TOGA) BUNYA
81
ANIMAL TRANSMITTED VIRUSES
RABIES | ARENA (LCMV)

Neuro (19 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions