viral infections Flashcards

1
Q

viruses

A
  • acellular pathogens that invade living cells (can’t survive without a host)
  • either kill host cell or alter its functions
  • composed of nucleic acid (DNA or RNA) surrounded by protein coat
  • viruses are microscopic agents visible only with an electron microscope
  • lack enzymes for energy production & protein synthesis
  • cannot grow or reproduce independently & need a host cell to replicate
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2
Q

parasites

A
  • organisms that live on or in a living host; relationship benefits the parasite & harms the host
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3
Q

mechanism of viral infection

A
  • viruses invade host cells & shed their protein coats
  • genetic material of the virus takes control of the host cell, directing it to produce more viruses
  • immune system fights viruses by producing substances such as interferon, which also cause symptoms of viral illnesses
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4
Q

contagious diseases

A
  • viral diseases are the most common forms of contagious diseases
  • contagious diseases can be transmitted from one person to another, often through respiratory droplets or hand-to-hand contact
  • examples; common cold & influenza
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5
Q

common cold

A
  • caused by over 200 different viruses, including rhinoviruses & coronaviruses
  • transmission primarily through hand-to-hand contact
  • prevention; frequent hand washing & avoiding touching the face after contact with others
  • symptoms; sore throat, runny nose, muscle aches, thick nasal discharge
  • OTC remedies can alleviate symptoms but do not cure viral infection
  • not caused by exposure to cold weather or being chilled, but more colds occur in fall and winter due to closer indoor contact
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6
Q

influenza (flu)

A
  • serious respiratory tract infection caused by influenza virus
  • highly infectious & adaptable; form changes so easily that every year new strains arise, making treatment difficult
  • symptoms; fever, extreme fatigue, headache, cough, muscle aches
  • spread via respiratory droplets
  • prevention; annual vaccination with vaccine updated each year to match circulating strains
  • treatment; medications can shorten the duration of illness if taken within one to two days of symptom onset
  • complications; can include pneumonia & other life-threatening conditions
  • highest infection rates are in children
  • compared with the common cold, influenza is more serious
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7
Q

measles & rubella

A
  • characterized by rash & fever
  • can cause severe complications like liver or brain infection or pneumonia
  • highly contagious
  • effective vaccination has significantly reduced cases
  • rubella (German measles);
  • mild illness but can cause severe birth defects if a pregnant woman is infected
  • vaccination has reduced incidence
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8
Q

mumps

A
  • causes swelling of the salivary glands
  • an lead to meningitis and, in males, inflammation of the testes
  • cases have decreased due to vaccination
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9
Q

chickenpox, coldsores, & herpesvirus infections

A
  • herpesviruses = large group of viruses that remain latent in body & can reactivate periodically
  • once infected, host is never free of the virus
  • virus lies latent within certain cells & becomes active periodically, producing symptoms
  • responsible for cold sores, mononucleosis, chicken pox, & STI herpes; frequently cause
    latent infections
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10
Q

varicella-zoster virus

A
  • included in herpesviruses
  • causes chicken pox & shingles
  • highly contagious childhood disease characterized by itchy rash made up of small blisters
  • complications more likely to occur in young infants & adults
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11
Q

epstein-barr virus (EBV), aka mono

A
  • included in herpesviruses
  • causes infectious mononucleosis
  • spread by intimate contact with saliva of infected person
  • fever, sore throat, swollen lymph nodes, & fatigue
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12
Q

cytomegalovirus (CMV) & human herpesvirus 8 (HHV-8)

A
  • included in herpesviruses
  • can cause severe infections in immunocompromised individuals
  • CMV injects lungs, brain, colon, & eyes
  • HHV-8linked to Kaposi’s sarcoma
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13
Q

viral encephalitis

A
  • inflammation of brain tissue caused by viral infection
  • causes; HSV-1, HIV, mosquito-borne viruses
  • symptoms; fever, headache, nausea, lethargy, memory loss, seizures, possible permanent brain damage or death
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14
Q

viral hepatitis

A
  • used to describe several different infections that cause inflammation of liver
  • hepatitis is usually caused by one of the three most common hepatitis viruses;
  • effective vaccines for hep A & B but new cases occur each year
  • symptoms; fatigue, jaundice, abdominal pain, loss of appetite, nausea, diarrhea
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15
Q

hepatitis A virus (HAV)

A
  • mild, transmitted by contaminated food or water
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16
Q

hepatitis B virus (HBV)

A
  • transmitted sexually
17
Q

hepatitis C virus (HCV)

A
  • transmitted through blood, common among injection drug users
  • chronic carriers; 5-10% of HBV infections & 85-90% of HCV infections become chronic
  • chronic carriers can infect others & may develop liver disease, cirrhosis, or liver cancer (some remain asymptomatic)
  • jaundice = characterized by yellowing of the skin and eyes due to increased bile pigment levels in the blood
18
Q

poliomyelitis (Polio)

A
  • infectious viral disease affecting nervous system
  • can cause irreversible paralysis & death in some individuals
  • dramatic decline in incidence in Canada post-vaccine introduction
  • North & South America now considered polio-free
19
Q

rabies

A
  • infectious viral disease caused by rhabdovirus, potentially fatal infection of central nervous system
  • transmission typically occurs through an animal bite
  • significant decline in human rabies-related deaths in Canada due to vaccination of domestic animals & development of post-exposure prophylaxis (PEP)
  • rare in Canada, with only 24 deaths since 1924
  • most recent cases traced to bats
  • PEP recommended for anyone with direct or possible indirect contact with a bat
  • PEP involves one dose of immunoglobulin and five doses of rabies vaccine over 28 days
20
Q

human papillomavirus (HPV)

A
  • consists of more than 100 different types causing various warts, including common, plantar, & genital warts
  • chronic infection can lead to recurring warts despite treatment
  • major cause of cervical cancer
  • treatments include OTC preparations & professional methods (laser surgery or cryosurgery)
  • 2 vaccines approved by Health Canada;
  • one for females aged 9 to 45 & males aged 9 to 26
  • second vaccine for females aged 9 to 26
21
Q

treating viral illnesses

A
  • antiviral drugs interfere with the viral life cycle, preventing entry into cells or reproduction within cells
  • available for HIV, influenza, herpes simplex, varicella-zoster, HBV, & HCV
  • most viral diseases must run their course without specific treatment
22
Q

fungi

A
  • absorb food from organic matter & can be multicellular (moulds) or unicellular (yeasts)
  • common fungi include mushrooms & moulds on bread & cheese
  • only about 50 species cause human diseases, typically affecting skin, mucous membranes, & lungs
23
Q

fungi diseases

A
  • Candida albicans; common in vagina; overgrowth causes yeast infections
  • factors include antibiotics, warm/moist clothing, pregnancy, oral contraceptives, & certain diseases.
  • symptoms; thick white or yellowish discharge
  • treatment; prescription and OTC available (self-treatment not recommended)
  • other conditions; athlete’s foot, jock itch, ringworm (mild and treatable)
  • systemic fungal diseases; severe, life-threatening, hard to treat
  • ex; histoplasmosis (common in Mississippi & Ohio River Valleys), coccidioidomycosis (California)
24
Q

protozoa

A
  • single-celled organisms, causing recurrent, cyclical disease attacks
  • release enzymes or toxins that destroy cells
  • millions affected by protozoa diseases in developing countries
25
Q

common protozoa diseases

A
  • malaria; caused by plasmodium, transmitted via mosquito bite
  • severe flu-like symptoms, may cause anemia
  • prevention & treatment drugs available (distribution challenging in remote areas)
  • giardiasis; caused by Giardia lamblia
  • nausea, diarrhea, bloating, abdominal cramps
  • transmission; contaminated food/water, surfaces
  • common in child care settings, travellers, hikers
  • rarely serious, treatable with medication
26
Q

other protozoal infections

A
  • trichomoniasis; vaginal infection, may increase HIV risk
  • trypanosomiasis; African sleeping sickness, transmitted by tsetse fly, causes severe symptoms and death
  • amoebic dysentery; caused by Entamoeba histolytica, results in bloody diarrhea, stomach pain, fever
27
Q

parasitic worms

A
  • largest infectious organisms, causing variety of mild infections
  • attack tissues or organs & compete with host for nutrients
  • some enter by burrowing through skin, others via undercooked pork or fish
  • adult worms can be meters long
28
Q

common parasitic diseases

A
  • tapeworms, hookworms, pinworms, flukes
  • pinworms; common in children, cause rectal itching, sleep difficulties
  • flukes; infect liver/lungs, potentially deadly
  • infections usually stem from contaminated food or drink, controllable by hygiene
29
Q

prions

A
  • proteinaceous infectious particles causing fatal central nervous system disorders
  • lack DNA/RNA, consist only of protein, do not trigger immune response
  • abnormal shape, form brain deposits
  • spongiform encephalopathies (TSEs), including Creutzfeldt-Jakob disease (CJD) & bovine spongiform encephalopathy (BSE, or mad cow disease)
  • symptoms; loss of coordination, weakness, dementia, death
  • transmission; inherited, genetic mutations, infected tissue consumption, medical procedures
30
Q

zika virus

A
  • emerging infectious disease
  • transmission; Aedes mosquitoes, sexual contact, mother to fetus
  • symptoms; mild (fever, rash, joint pain), potential for Guillain-Barré syndrome
  • pregnancy concerns; birth defects (microcephaly, growth impairment, eye defects)
31
Q

west nile virus

A
  • emerging infectious disease
  • transmission; mosquitoes from infected birds
  • symptoms; mild or none, potential brain damage or death
  • vaccine development ongoing
32
Q

SARS

A
  • emerging infectious disease
  • transmission; originally from wildlife, spread rapidly
  • symptoms; pneumonia, fatal in 4% of cases
  • outbreak; controlled since 2004
33
Q

rotavirus

A
  • emerging infectious disease
  • transmission; poor hygiene/sanitation
  • symptoms; gastroenteritis in children, severe diarrhea
34
Q

E. coli O157:H7

A
  • emerging infectious disease
  • transmission; contaminated food/water
  • symptoms; bloody diarrhea, kidney damage
35
Q

hantavirus

A
  • emerging infectious disease
  • ransmission; rodent droppings/urine
  • symptoms; pulmonary syndrome, high fatality rate
36
Q

ebola

A
  • emerging infectious disease
  • transmission; contact with infected bodily fluids
  • symptoms; hemorrhagic fever, high fatality
  • outbreaks; primarily in Africa, 2014 outbreak largest recorded
37
Q

other immune disorders

A
  • cancer; immune system detects & destroys cancerous cells
  • breakdown in immune response allows cancer to proliferate
  • autoimmune diseases; immune system mistakenly attacks body’s own cells
  • common autoimmune diseases: rheumatoid arthritis, systemic lupus erythematosus
  • autoimmune disorders more common in women
38
Q

factors contributing to emerging infections pt1

A
  • drug resistance = increasing resistance in malaria, tuberculosis, gonorrhea, influenza, AIDS, pneumococcal, & staphylococcal infections
  • consequence; prolonged illness, higher mortality, more expensive treatments
  • poverty = over 1 billion in extreme poverty, lack access to essential drugs
  • urbanization, overcrowding, migration spread diseases
  • public health breakdown = poor infrastructure, contaminated water, inadequate vaccination
  • natural disasters disrupt public health systems
  • travel & commerce = increased global travel and trade spread infectious agents
  • notable examples: SARS, cholera reintroduction, Zika spread
39
Q

factors contributing to emerging infections pt2

A
  • mass food production & distribution = long-distance food travel increases contamination risk
  • chance contamination can lead to widespread illness
  • human behaviours = injectable drug use spreads HIV/hepatitis
  • changes in sexual behaviour increase STIs
  • daycare use increases certain infections
  • bioterrorism = deliberate release of infectious agents like anthrax, smallpox, plague, botulism, and viral hemorrhagic fevers
  • high concern for public health
  • climate change = longer warm periods, milder winters allow pathogenic species to expand range
  • insects, vectors more active in previously unaffected regions