Viral Hepatitis- Verma

Question 1

What is this:
injury to the liver with inflammation of the liver cells

What can cause it?

Answer 1

hepatitis

bacteria, drugs, toxins, and excess alcohol, VIRUSES

Question 2

Viral hepaptitis is caused by which viruses?

Answer 2

Hep A
Hep B
Hep C
Hep D
Hep E

Question 3

What is the most common liver infection in the US?

Answer 3

Viral hepatitis

Question 4

What types of Hepatitis are transmitted by fecal oral?

Answer 4

Hep A and Hep E

Question 5

What types of hepatitis are transmitted by blood?

Answer 5

Hep B, C and D

Question 6

Acute hepatitis lasts for less than (bank) months. All these viruses can cause acute or short term effects.

Answer 6

6 months

Question 7

Chronic hepatitis lasts for more than (blank) months. Which viruses cause chronic or life-long infections?

Answer 7

6 months

-B, C, D

Question 8

Chronic hepatitis can lead to (blank x 3)

Answer 8

cirrhosis, liver failure, liver cancer

Question 9

What are the ways to get hep A transmission?

Answer 9

fecal oral
close personal contact
contaminated food/water
blood exposure (rare)

Question 10

Hep A is common where?

Answer 10

in poor areas with bad hygiene,-> lots of childhood infection

Question 11

What kind of close personal contact can cause Hep A transmission?

Answer 11

• Household, child day care centers
• Sexual promiscuity
• contact with HAV

Question 12

What 2 types of people will drink or eat contaminated food or water and get Hep A?

Answer 12

immigrants or travelers

Question 13

Hep A accounts for (blank)% of all cases of acute viral hepatitis. Who are at risk to get this?

Answer 13

44%
Persons living in crowded areas
Children./works in day care
Homosexual men
Residents and travelers in underdeveloped countries

Question 14

Hep E is (common/uncommon) and occurs as a result of travel to developing countries. What groups are at risk?

Answer 14

uncommon

persons living in developing nations, refugee camps, overcrosed housing

Question 15

A 56-year-old Southeast Asian immigrant is diagnosed with chronic hepatitis B virus infection. Considering the epidemiology of this infection in endemic countries, what is the most likely way that this man became infected?

Answer 15

Perinatally

Question 16

A 23-year-old woman presented with an insidious onset of fever, fatigue, joint pain, nausea, anorexia, and abdominal pain. Physical exam revealed hepatomegaly. Serologic tests indicated acute infection with hepatitis B virus. Considering the epidemiology of this disease in the United States, what would the history of the above patient most likely include?

Answer 16

unprotected sex with multiple partners

Question 17

How do you characterize Hep B?

Answer 17

HBV antigens and host antibodies
HBsAg (surface antigen)
HBcAg (core antigen)
HBe Ag (envelope antigen)

Question 18

What is the first serological marker to rise with Hep B?

Answer 18

HBsAG

Question 19

(blank) forms part of the envelope of HBV. Exist in (blank) quantities in the serum.

Answer 19

HBsAg

Question 20

What does an HBs Ag positive person indicate?

Answer 20

over HBV infection but not necessarily liver disease

Question 21

If you have anti HBsAb then what does this indicate?

Answer 21

you have immunity to HBV

Question 22

What will you find in a HBV patient with hep immunity due to natural infection?

Answer 22

anti HBc

anti HBs

Question 23

What will you find in a HBV patient with an acute infection?

Answer 23

HBsAg
anti IgM
anti HBc

Question 24

What will you find in a HBV patient with a chronic infection?

Answer 24

HBs Ag

Anti HBc

Question 25

MSM are at no greater risk of (blank) infection than the general population.

Answer 25

HCV

Question 26

What does Anti HBc tell you? What does anti IgM HBc tell you? What does HBsAg tell you? What does anti HBs tell you?

Answer 26

exposure acute exposure infection Immunity

Question 27

What kind of virus is Hep C? How big is it? How many serotypes?

Answer 27

RNA virus 55 nm Diameter one serotype

Question 28

the 5 year survival in patints with HCC is (blank)

Answer 28

less than 5%

Question 29

If you have an Anti HCV positive and HCV RNA positive test, then what does this indicate?

Answer 29

acute or chronic HCV depending upon clinical context

Question 30

If you have a positive anti HCV and a negative HCV RNA, then what does this indicate?

Answer 30

Resolution of HCV

Question 31

If you have a positive HCV RNA and a negative anti-HCV, the what does it indicate?

Answer 31

early acute HCV or chronic HCV in immunosuppressed states

Question 32

If you have negative anti HCV and negative HCV RNA then what does this indicate?

Answer 32

Absence of HCV