viral hepatitis treatment Flashcards

1
Q

tenofovir disoproxil moa

A

pro-drug for tenofovir; nucleotide analog of adenosine-5-monophosphate, causes inhibition of HBV polymerase and produces chain termination

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2
Q

entecavir moa

A

guanosine nucleoside analog that inhibits HBV viral polymerase

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3
Q

tenofovir and entecavir metabolism and excretion

A

eliminated unchanged in the urine, no CYP interactions

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4
Q

tenofovir bioavailability

A

taken with high fat meal increases bioavailability

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5
Q

entecavir bioavailability

A

food delays absorption

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6
Q

tenofovir adverse effects

A

acute renal failure (rare), osteoporosis, bone pain, and fractures- give Ca and Vit D supplements
hepatotoxicity due to inhibition of mitochondrial DNA polymerase gamma

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7
Q

treatment of confection of HBV and HIV

A

tenofovir and emtricitabine

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8
Q

interferon moa

A

bind to the cell surface and activate tyrosine kinases that leads to the production of IFN-stimulated enzymes, causing an anti proliferative and immunomodulatory effect

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9
Q

interferon toxicity

A

dose-limiting neuropsychiatric issues: depression, somnolence, confusion, behavioral changes, and seizures;
anemia, myelosuppression with granulocytopenia and thrombocytopenia
hepatic enzyme elevation and triglyceride elevation

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10
Q

treatment of HCV-1

A

PEG-interferon and ribavirin for 24-48 weeks + telaprevir, boceprevir, or simeprevir

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11
Q

ribavirin moa

A

enhances hot t-cell immune clearance of HCV, inhibition of host IMPDH which depletes pools of GTP, and directly inhibits HCV replication;
minimal effect on decreasing HCV RNA but works synergistically with interferon

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12
Q

ribavirin tox

A

primary toxicity is hemolytic anemia
can cause MI and difficulty breathing secondary to anemia
teratogen (male and female)

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13
Q

telaprevir and boceprevir moa

A

NS3/4 serine protease inhibitors

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14
Q

protease inhibitor adverse effects

A

potential interactions via CYP 3A4/5
exacerbation of anemia
teratogenicity due to the co-administration with ribavirin

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