C Diff Tx

Question 1

metronidazole MOA

Answer 1

metabolized by anaerobic bacteria to metabolites toxic to RNA/DNA synthesis

Question 2

fidaxomycin moa

Answer 2

macrolide that inhibits RNA polymerase; bactericidal against c. diff

Question 3

metronidazole adverse effects

Answer 3

nausea, peripheral neuropathy, tertogenic, enters placenta and breast milk

Question 4

mild-mod c. diff

Answer 4

oral metronidazole

Question 5

severe c. diff

Answer 5

oral vancomycin

Question 6

complicated c. diff

Answer 6

high dose oral vanc. and IV metronidazole

Question 7

c. diff in pregnancy

Answer 7

oral vancomycin

Question 8

1st recurrence

Answer 8

same protocol

Question 9

2nd recurrence

Answer 9

oral vanc. with extended treatment