Viral GI Micro-Deebs Flashcards
Cause of death from Norovirus?
DEHYDRATION
What 2 things does the stool of a person infected with viral Gastroenteritis NOT INCLUDE?
WBCs
Blood
Age group and time of year of Rotavirus?
Less than 5 years old (less than 2 is more severe)
Winter
Setting associated with Rotavirus?
School or daycare
Setting for Norovirus?
Common-source…linked to food or water
ALL PEOPLE GET SICK AT SAME TIME
CHIPOTLE!
Properties of Rotavirus?
RNA
Icosahedral capsid
Non-enveloped
DS segmented genome
Class of Rotavirus genome?
Class III
*thats kind of rare!
Tropism for Rotavirus?
Mature absorptive villous epithelium in upper 2/3 of small intestine
*confined to mucosa
What does Rotavirus have that is rare for a virus?
What does it do?
Toxin!
It acts on the epithelium to poke holes and electrolytes leak out…causing water to stay in the lumen
How long is someone infected with Rotavirus contagious?
2-5 days after diarrhea starts
Incubation period for Rotavirus?
2 days
What activates Rotavirus?
The digestive enzymes in the stomach! So once the viral particle has repilicated in the small intestine…the new virions are not directly toxic to the cells they encounter
What is ISVP?
Intermediate Sub-viral particle of Rotavirus…After it has been activated in the stomach and it is on its way to the Small intestine!
What Group of the VP6 element of Rotavirus infects humans?
Group A
How do you detect Rotavirus in an infected person?
RT-PCR
ELISA
Latex agglutination…