GI Immunology-Clarke Flashcards
What cells are responsible for Immune tolerance?
Treg (TH17)
What type of T cells are predominant in the central immune system?
TH1
What type of T cells are predominant in the surface/barrier immune system?
TH2
Antibody in central immune system?
IgG
Antibody in Mucosa?
IgA
What 2 locations of the bowel have germinal centers?
Peyer’s Patches
Mesenteric Lymph nodes
What type of response occurs in germinal center?
Cell-mediated, humoral response
*What attracts CD8+ T cells to the villi of the upper small intestine?
B7 integrin
*What is the ligand for B7 on effector T cells?
MADCAM1 ….a selectin
What type of cell is found in Peyer’s patches that detects antigen and pulls it into the epithelium?
M cells
Paneth cells have a lot of ___________ which leads to the production of Defensin.
NOD2
What transcription factor controls ALL inflammatory responses?
NFKB
What PAMP binds TLR4?
LPS (gram-)
***What type of T cells are mostly present in the top of the small intestine?
Which MHC do they recognize?
CD8+ cytotoxic T cells
MHC I
***What type of T cells predominate in the lamina propria?
Which MHC do they recognize?
CD4+ T cells
MHC II
Describe what happens when M cells detect antigen.
They mediate antigen transfer from gut lumen…dendritic cells pick up the material and display it to T cells…T cells help direct the type of antibody that a B cell will develop…Usually IgA or IgM
What enzymes do Paneth cells contain that block entryy of an antigen?
Lysozyme, PLA2
What cells take up oral vaccines?
M cells !
What is produced by ALL cells that leads to an increase in MHC I expression?
IFN Type I
Where does antibody produced in mesenteric lymph nodes go?
OPEN CIRCULATION
AKA everywhere
How do neutrophils directly kill pathogens?
ROS
Which antibody leads to expulsion of parasites? Where is it made?
IgE
Made in mesenteric lymph nodes
What does TLR2 detect?
Gram + bacteria
What IL regulates Treg cells?
IL-10
