viral drugs I keep missing

Question 1

the one drug used to treat pox virus family? hint: one of the ones with diff MOA

Answer 1

cidofovir

Question 2

3 drugs used to treat varicella zoster? FAV

Answer 2

acyclovir, valacyclovir, famciclovir

Question 3

2 drugs used to treat varicella chicken pox?

Answer 3

acyclovir, valacyclovir

Question 4

4 drugs used to treat HHV-6? 2 weird ones + 2 related ones

Answer 4

cidofovir, foscarnet, ganciclovir, valganciclovir

Question 5

one drug used to treat HHV-7?

Answer 5

cidofovir

Question 6

4 drugs used to treat HHV-8?

Answer 6

cidofovir, famciclovir, ganciclovir, valacyclovir

Question 7

2 drugs used to treat HHV-8 infection

Answer 7

ganciclovir and valganciclovir

Question 8

two antiviral drugs that do not require intracellular kinase-dependent phosphorylation for activity. they retain efficacy vs. kinase-deficient strains

Answer 8

cidofovir and forscarnet

Question 9

MOA for acyclovir, famciclovir, ganciclovir, valacyclovir, valganciclovir,

Answer 9

competitively inhibit viral DNA polymerase; competes with deoxyguanosine triphosphate for incorporation into viral DNA

Question 10

MOA for cidofovir

Answer 10

competitively inhibit viral DNA polymerase; compestes with deoxycytosine triphosphate for incorporation into viral DNA

Question 11

MOA for foscarnet

Answer 11

selectively inhibits the viral-specific DNA polymerases and reverse transcriptase at pyrophosphate binding site; blocks chain elongation

Question 12

ADE for acyclovir

Answer 12

neurotoxicity including seizures

Question 13

ADE for cidofovir

Answer 13

nephrotoxicity - monitor; creatinine and urinary protein; probenecid hypersensitivity

Question 14

ADE for famciclovir

Answer 14

NO significant issues!!

Question 15

ADE for foscarnet

Answer 15

electrolyte imbalance; chelates Ca2+ ions

Question 16

ADE for ganciclovir. think PANT LT

Answer 16

anemia, luekopenia, neutropenia, pancytopenia, and thrombocytopenia; teratogen

Question 17

ADE for valacyclovir

Answer 17

as for acyclovir (neurotoxicity including seizures)

Question 18

ADE for valganciclovir

Answer 18

as for ganciclovir (anemia, leukopenia, neutropenia, panyctopenia, and thrombocytopenia, teratogen)

Question 19

this drug is metabolized to penciclovir

Answer 19

famciclovir

Question 20

these two drugs are prodrugs

Answer 20

valacyclovir and valganciclovir

Question 21

why do patients receive oral probenecid while taking cidofovir

Answer 21

to minimize potential for renal toxicity, patients receive oral probenecid and hydration with normal saline concurrently