intro to skin biology: anatomy of the skin

Question 1

what is the function of filaggrin?

Answer 1

retains water within keratinocytes

Question 2

mutations in filaggrin account for which disesases?

Answer 2

atopic dermatitis, asthma

Question 3

good description of basal cell carcinoma

Answer 3

Most commonly presents as pearly, erythematous papules or plaques with rolled borders and telangectasias in sun- exposed areas.

Question 4

what is a common skin disease in which langerhans cells play a prominent role?

Answer 4

contact dermatitis

Question 5

epidermolysis bullosa simplex = genetic mutations in which keratins

Answer 5

keratin 5/14

Question 6

what is a nevus?

Answer 6

benign collection of melanocytes

Question 7

what is a melanoma?

Answer 7

growth of malignant(cancerous) melanocytes

Question 8

what is erythema nodosum?how does it appear?

Answer 8

inflammation of the subcutis; clinically appears as deep seated erythematous nodules, typically on the shins

Question 9

etiology of erythema nodosum?

Answer 9

erythema nodosum may be idiopathic or a reaction to infections, medication, or an underlying autoimmune disease

Question 10

epidermis
what is function?
associated diseases

Answer 10

function: permeability barrier

associated disease: atopic dermatisis

Question 11

epidermis, dermis
function
associated diseases

Answer 11

function: protection from pathogens
disease: molluscum contagiosum

Question 12

epidermis, dermis, subcutis
function:
disease

Answer 12

function: thermoregulation
disease: hyperthermia

Question 13

epidermis
function: UV procection
associated disease:

Answer 13

disease: albinism

Question 14

epidermis, dermis, subcutis
function: sensation
disease?

Answer 14

disease: diabetic neuropathy

Question 15

epidermis, dermis
function: wound repair/regeneration
disease?

Answer 15

venous stasis ulcer, keloid

Question 16

epidermis, dermis, subcutis
function: physical appearance
disease?

Answer 16

lipodystrophy