Viral Bugs

Question 1

Calicovirus:

• 2 types?
• Type of virus?
• Capsid? Naked?
• Often found on what? In what food?
• FUT2 gene?
• LAV Vaccine available?

Answer 1

• Noro/saparo
• ssRNA(+) linear
• Icosahedral; yes
• Cruise ships; shellfish
• Resistance
• Yes

Question 2

Rotavirus:

• Type of virus? Worldwide mortality?
• Shell? Proteins? Enveloped?
• Causes what to villi? (4)
• Often reassorts in whom?
• Invades where? Replicates where? Response?
• Enterotoxin NSP4 leads to ? Then?
• Vaccine risk?

Answer 2

• dsRNA; yes
• yes; 3 on shell; no
• destriction, atrophy, less Na+ abs; loss of K+
• Animals
• Small intestine; epi; mononuclear
• Increase IC Ca2+, Increase Cl- excretion
• Intussception

Question 3

Adenovirus:

• Enveloped? Shape?
• Type of virus?
• Causes what dz? (2)
• Seasonality?

Answer 3

• No; icosahedral
• dsDNA
• UTI’s and Enteric gastritis
• None

Question 4

Astrovirus:

• Enveloped?
• Type of virus?
• Needs what?

Answer 4

• None
• ssRNA
• Trypsin

Question 5

HPV:

• Type of virus? Enveloped?
• “O” virus? (3)
• Types of cancer? (2)
• Structure: On capsid? Histones? Early genes? Late? LCR? Which are oncogenes?
• Infection starts where? And goes? Located where?
• E6/7 do what?
• Anogenital strains? Cancer?
• Warts treatment? Cancer treatment? (2)

Answer 5

• dsDNA circular; none
• Os, Round warts, circular dsDNA
• Head, neck, cervical
• L1/L2; yes; 7; 2; 1; E5-7
• Deep; moves up to shed; SC junction
• Degrade p53/ phos. RB to inactivate
• HPV 6, 11; HPV 16, 18, 31
• Cream; LEEP/ cyrosurgery

Question 6

Herpes General:

• Structure? Shape? Enveloped?
• Held at bay via?
• Alphas? Latent where?
• Beta? Latent where?
• Gammas? Latent where?
• Treat alpha with? Targets?
• Treat alpha and beta with?

Answer 6

• dsDNA; Icoasahedral; enveloped
• Cell mediated response
• HSV1/2; VZV; DRG
• CMV/HHV6/7; Myeloid/endothelia
• EBV/KSV; B Cells
• Acyclovir; Thymaidine Kinase
• Ganciclovir

Question 7

• HSV 1 (HHV1):
• 3 pathologies?
• Transmitted via?
• Latent where?
• 20% get what?
• Primary outbreak?
• Worse outcomes in who? (3)

Answer 7

• Gingivostomatitis, keratoconjunctivitis, temp lobe enceph
• Saliva
• Trigeminal DRG
• Systemic symptoms
• Worse than subsequent
• Neonate, immunocomp, T cell deficient

Question 8

• HSV 2 (HHV2):
• Pathology?
• Neonatal what?
• Latent where?
• Placenta?
• 3 complications?

Answer 8

• Genital
• Herpes
• Sacral ganglia DRG
• Can cross
• Yeast infection, meningitis, urethritis

Question 9

• VZV (HHV 3):
• 3 pathologies?
• Major morbidity via?
• Latent where?
• Transmitted via?
• Vaccine available?

Answer 9

• Chickenpox/shingles, encephalitis, pneumonia
• Post-herpetic neuralgia
• Dorsal root of Trigeminal nerve
• Oral secretions
• Avaliable

Question 10

• CMV (HHV5):
• In adults? (3) Cells look like?
• Congenital? (3)
• Transmitted via?
• Infects? (2)
• Monospot test?
• Causes what in immune compromised?
• AIDS? Bone Marrow transplant?

Answer 10

• Mono (owl eyes), pneuomona, reitinits
• Jaundice, hepatospleno, small head
• All body secretions
• CD34 bone marrow, endothelium
• Negative
• End organ anywhere
• Retinitis, Pneumonia

Question 11

• HHV 6/7 (Roseola):
• Disease progression?
• Infects cells located where?
• HHV6 ab’s by when? HHV7?

Answer 11

• High fever/ seizures –> diffuse macropapular rash
• Back of throat
• 2yo; 4yo

Question 12

• EBV (HHV4):
• Causes 3 pathologies? Cells of each?
• Infects what cells? Transforms?
• Monospot test?
• Heterophil test does what?
• RS in what? CD15/30?

Answer 12

• Burkitts (memory cells); Hogkins (Follicular/mantle germinal cells); mononucleosis
• B cells; yes
• Positive
• Ab agglut RBC’s of an animal
• Hodgkins; positive

Question 13

KSV (HHV 8):

• Neoplasm in?
• Seen in who? (3)
• Transmitted via?
• Purple spots where? (2)
• Latent in what?

Answer 13

• Endothelial cells
• HIV, Transplant, Immunocompromised
• Sexual contact
• Body and oral pharynx
• B cells