Antibiotics Flashcards
1
Q
Pen G:
- Type?
- MOA?
- PK?
- AR’s?
- Spectrum?
A
- Penicillin
- Cidal; Inhibit cell wall synthesis
- Renal; IV/IM
- Type 1, Type 3 hypersensitivity
- Gram +/- cocci; Gram + Bacilli; Anaerobes
2
Q
Pen V:
- Type?
- MOA?
- PK?
- AR’s?
- Spectrum?
A
- Penicillin
- Cidal; Inhibit cell wall synthesis
- Renal; PO
- Type 1, Type 3 hypersensitivity
- Gram +/- cocci; Gram + Bacilli; Anaerobes
3
Q
Methicillin:
- Type?
- MOA?
- PK?
- AR’s?
- Spectrum?
A
- Penicillinase- resistant
- Cidal; Inhibit cell wall synthesis
- Hepatic; IV/IM/PO
- Type 1, Type 3 hypersensitivity
- Gram +/- cocci; Gram + Bacilli; Anaerobes (B-lactamase SA)
4
Q
Oxacillin:
- Type?
- MOA?
- PK?
- AR’s?
- Spectrum?
A
- Penicillinase- resistant
- Cidal; Inhibit cell wall synthesis
- Hepatic; IV/IM/PO
- Type 1, Type 3 hypersensitivity
- Gram +/- cocci; Gram + Bacilli; Anaerobes (B-lactamase SA)
5
Q
Ampicillin:
- Type?
- MOA?
- PK?
- AR’s?
- Spectrum?
A
- Extended spectrum
- Cidal; Inhibit cell wall synthesis
- Renal; PO
- Type 1, Type 3 hypersensitivity (GI upset)
- Gram +/- cocci; Gram + Bacilli; Anaerobes (many gram -, Enterobacteriae, H Flu, E coli)
6
Q
Amoxicillin:
- Type?
- MOA?
- PK?
- AR’s?
- Spectrum?
A
- Extended spectrum
- Cidal; Inhibit cell wall synthesis
- Renal; PO
- Type 1, Type 3 hypersensitivity (GI upset)
- Gram +/- cocci; Gram + Bacilli; Anaerobes (many gram -, Enterobacteriae, H Flu, E coli)
7
Q
Piperacillin:
- Type?
- MOA?
- PK?
- AR’s?
- Spectrum?
A
- Anti pseudomonal
- Cidal; Inhibit cell wall synthesis
- IV; Renal
- Type 1, Type 3 hypersensitivity
- Gram +/- cocci; Gram + Bacilli; Anaerobes (Less gram +, more gram -; pseudomonas
8
Q
Cephalexin:
- Type?
- MOA?
- PK?
- AR’s?
- Spectrum?
A
- 1st gen Ceph
- Cidal; Inhibit cell wall synthesis
- Renal; IV/PO
- Type 1, Type 3 hypersensitivity
- Less allergy than penicillin
- Gram + cocci; gram - (E. Coli/ Klebsiella)
9
Q
Cefazolin:
- Type?
- MOA?
- PK?
- AR’s?
- Spectrum?
A
- 1st gen Ceph
- Cidal; Inhibit cell wall synthesis
- Renal; IV/PO
- Type 1, Type 3 hypersensitivity
- Less allergy than penicillin
- Gram + cocci; gram - (E. Coli/ Klebsiella)
10
Q
Cefuroxime:
- Type?
- MOA?
- PK?
- AR’s?
- Spectrum?
A
- 2nd gen gen Ceph
- Cidal; Inhibit cell wall synthesis
- Renal; IV/PO
- Type 1, Type 3 hypersensitivity
- Less allergy than penicillin
- Extended gram - (H Flu, Enterobacter) Gram + cocci; gram - (E. Coli/ Klebsiella)
11
Q
Ceftriaxone:
- Type?
- MOA?
- PK?
- AR’s?
- Spectrum?
A
- 3rd gen Ceph
- Cidal; Inhibit cell wall synthesis
- Renal; IV/PO (GOOD CNS)
- Type 1, Type 3 hypersensitivity
- Less allergy than penicillin
- Greatest gram - (some anti-pseudomonal)
12
Q
Aztreonam:
- Type?
- MOA?
- PK?
- Spectrum?
A
- Monobactam
- Cidal; Inhibit cell wall synthesis
- IV/ Renal
- Narrow: Gram (-) aerobic
13
Q
Carbapenam:
- MOA?
- PK?
- AR’s?
- Spectrum?
A
- Cidal; Inhibit cell wall synthesis
- IV / Renal
- GI upset
- Wide: Ceph resistant organisms
14
Q
Vancomyocin:
- MOA?
- PK?
- AR’s?
- Spectrum?
A
- Cidal; Inhibit cell wall synthesis
- IV/ Renal
- Renal
- Renal toxicity, ototoxicity, chills, fever, rash
- Narrow: Gram + cocci
15
Q
Ciprofloxacin:
- Type?
- MOA?
- PK?
- AR’s?
- Spectrum?
A
- Fluoroquinolones
- Cidal; inhibit DNA gyrase
- Bone, CNS; Renal/Hepatic
- Not with anatacids or kids
- Gram - aerobes; UTI’s