Pharm Flashcards
1
Q
Cimetidine:
- Drug Type?
- MOA?
- SE? (5)
A
- H2 Blocker
- Reversible H2 block to decrease parietal H+ release
- P450 inhibitor (Cim), High prolactin, gynecomastia, cross placenta, increase Cr (Cim/Ram)
2
Q
Ranitidine:
- Drug Type?
- MOA?
- SE? (5)
A
- H2 Blocker
- Reversible H2 block to decrease parietal H+ release
- P450 inhibitor (Cim), High prolactin, gynecomastia, cross placenta, increase Cr (Cim/Ram)
3
Q
Omeprazole:
- Drug Type?
- MOA?
- SE? (4)
A
- PPI
- Inhibit H+/K+/ATPase in stomach parietal cells
- Risk of C.Diff, Pneumonia, Hip fracture, Low Mg2+
4
Q
Esomeprazole:
- Drug Type?
- MOA?
- SE? (4)
A
- PPI
- Inhibit H+/K+/ATPase in stomach parietal cells
- Risk of C.Diff, Pneumonia, Hip fracture, Low Mg2+
5
Q
Bismuth/Sucrulfate:
- MOA?
- Use? (2)
A
- Binds ulcer base
- Ulcers/ Travellers Diarrhea
6
Q
Misoprostol:
- MOA?
- Use?
- SE? (2)
A
- PGE1 analog
- NSAID induced peptic ulcers
- Diarrhea, induced labor
7
Q
Octreotide:
- MOA?
- Use? (4)
- SE? (3)
A
- Somatostatin analog
- Variceal bleeds, VIPoma, Carcinoid, Acromegaly
- Nausea, cramps, diarrhea
8
Q
Aluminum Hydroxide:
- Use?
- SE? (5)
A
- Antacid
- hypokalemia, constipation, low phosphate, muscle weakness, osteodytrophy, seizures
9
Q
Calcium Carbonate:
- Use?
- SE? (3)
A
- Antacid
- hypokalemia, high calcium, rebound acid
10
Q
Magnesium Hydroxide:
- Use?
- SE? (5)
A
- Antacid
- hypokalemia, diarrhea, hyporeflexia, hypotension, cardiac issues
11
Q
Polyethylene Glycol:
- MOA?
- Use?
- SE? (3)
A
- Osmotic laxative
- Constipation
- Diarrhea, dehydration, abused by bilumics
12
Q
Ifliximab:
- MOA?
- Use? (5)
- SE? (3)
A
- Anti-TNFa
- Crohns, UC, AS, Psiorisis, RA
- TB, Fever, Hypotension
13
Q
Sulfasalazine:
- MOA?
- Use? (2)
- SE? (3)
A
- Antibiotic and anti-inflammatory; acivated by bacteria
- UC, Crohns
- Sulfa drunk rxn, nausea, oligospermia
14
Q
Odansetron:
- MOA?
- Use?
- SE? (2)
A
- 5HT3 antag., decrease vagal stim
- Antiemetic
- HA, constipation
15
Q
Metoclopromide:
- MOA?
- Use? (2)
- SE? (3)
A
- D2 antagonist
- Prokinetic; increases resting tone
- Parkinsonian like symptoms, diarrhea, depression
16
Q
Lispro:
- Drug type?
- Action?
- SE? (2)
A
- Rapid acting insulin
- Bind insulin receptor
- Hypoglycemia, hypersensitivity reaction
17
Q
Aspart:
- Drug type?
- Action?
- SE? (2)
A
- Rapid acting insulin
- Bind insulin receptor
- Hypoglycemia, hypersensitivity reaction
18
Q
Glulisine:
- Drug type?
- Action?
- SE? (2)
A
- Rapid acting insulin
- Bind insulin receptor
- Hypoglycemia, hypersensitivity reaction
19
Q
Insulin Regular:
- Drug type?
A
- Short acting
20
Q
Insulin NPH:
- Drug type?
A
- Intermediate
21
Q
Glargine:
- Drug type?
A
- Long acting
22
Q
Detemir:
- Drug type?
A
- Long acting
23
Q
- Metformin:
- Drug type?
- MOA?
- SE? (2)
A
- Biguanides
- Increase peripheral SI
- Lactic Acidosis in renal failure, GI upset
24
Q
Tolbutamide:
- Drug Type?
- MOA?
- SE? (2)
A
- First gen Sulfanylurea
- Close K+ to release insulin
- Hypoglycemia in renal failure, disulfaram like reaction
25
Chlorpropramide:
- Drug Type?
- MOA?
- SE? (2)
- First gen Sulfanylurea
- Close K+ to release insulin
- Hypoglycemia in renal failure, disulfaram like reaction
26
Glyburide:
- Drug Type?
- MOA?
- SE? (2)
- Second gen Sulfanylurea
- Close K+ to release insulin
- Hypoglycemia in renal failure
27
Glimepiride:
- Drug Type?
- MOA?
- SE? (2)
- Second gen Sulfanylurea
- Close K+ to release insulin
- Hypoglycemia in renal failure
28
Glipizide:
- Drug Type?
- MOA?
- SE? (2)
- Second gen Sulfanylurea
- Close K+ to release insulin
- Hypoglycemia in renal failure
29
Pioglitazone:
- Drug type?
- MOA?
- SE? (4)
- TZD
- Increased periph. SI
- Weight gain, CHF, Hepatotoxicity, Edema
30
Rosiglitazone:
- Drug type?
- MOA?
- SE? (4)
- TZD
- Increased periph. SI
- Weight gain, CHF, Hepatotoxicity, Edema
31
Acarbose:
- Drug type?
- MOA?
- SE?
- a glucosidase inhibitors
- Inhibit a-glucosidase brush border
- GI upset
32
Miglitol:
- Drug type?
- MOA?
- SE?
- a glucosidase inhibitors
- Inhibit a-glucosidase brush border
- GI upset
33
Polythiourcil:
- MOA?
- Clinical use? (2)
- SE? (3)
- Block TPO for decrease T4 to T3
- Hyperthyroidism; pregnancy
- Agranulocytosis, skin rash, hepatotoxicity
34
Methimazole:
- MOA?
- Clinical use?
- SE? (3)
- Block TPO for decrease T4 to T3
- Hyperthyroidism
- Agranulocytosis, skin rash, hepatotoxicity
35
Levothyroxine:
- MOA?
- Use?
- SE? (4)
- T4
- Hypothyroidism
- Tachy, heat intolerance, tremors, arrythmias
36
Triiodothyronine:
- MOA?
- Use?
- SE? (4)
- T3
- Hypothyroidism
- Tachy, heat intolerance, tremors, arrythmias
37
DDAVP:
| - Use?
- Central DI
38
Demeclocycline:
- MOA?
- Use?
- SE? (3)
- ADH antagonist
- SIADH
- Nephro DI, Photosensitivity, Bone/teeth abnormalitites
39
Quinidine:
- Drug type?
- MOA?
- Use?
- SE? (5)
- Class 1a sodium channel block
- Slow conduction (in depol. cells), decrease phase 0 slope, increase threshold for firing, state dependent, hyperkalemia leads to toxicity
- Increase AP duration, increase effective refractory period, increase QT interval
- Tinnitus, HA, thrombocytopenia, torsades de pointes due to increased QT interval
40
Procainimide:
- Drug type?
- MOA?
- Use?
- SE? (5)
- Class 1a sodium channel block
- Slow conduction (in depol. cells), decrease phase 0 slope, increase threshold for firing, state dependent, hyperkalemia leads to toxicity
- Increase AP duration, increase effective refractory period, increase QT interval
- reversible SLE like syndrome, HA, thrombocytopenia, torsades de pointes due to increased QT interval
41
Discopyramide:
- Drug type?
- MOA?
- Use?
- SE? (5)
- Class 1a sodium channel block
- Slow conduction (in depol. cells), decrease phase 0 slope, increase threshold for firing, state dependent, hyperkalemia leads to toxicity
- Increase AP duration, increase effective refractory period, increase QT interval
- Heart failure, HA, thrombocytopenia, torsades de pointes due to increased QT interval
