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Step 1 Study > Pharm > Flashcards

Pharm Flashcards

1
Q

Cimetidine:

  • Drug Type?
  • MOA?
  • SE? (5)
A
  • H2 Blocker
  • Reversible H2 block to decrease parietal H+ release
  • P450 inhibitor (Cim), High prolactin, gynecomastia, cross placenta, increase Cr (Cim/Ram)
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2
Q

Ranitidine:

  • Drug Type?
  • MOA?
  • SE? (5)
A
  • H2 Blocker
  • Reversible H2 block to decrease parietal H+ release
  • P450 inhibitor (Cim), High prolactin, gynecomastia, cross placenta, increase Cr (Cim/Ram)
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3
Q

Omeprazole:

  • Drug Type?
  • MOA?
  • SE? (4)
A
  • PPI
  • Inhibit H+/K+/ATPase in stomach parietal cells
  • Risk of C.Diff, Pneumonia, Hip fracture, Low Mg2+
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4
Q

Esomeprazole:

  • Drug Type?
  • MOA?
  • SE? (4)
A
  • PPI
  • Inhibit H+/K+/ATPase in stomach parietal cells
  • Risk of C.Diff, Pneumonia, Hip fracture, Low Mg2+
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5
Q

Bismuth/Sucrulfate:

  • MOA?
  • Use? (2)
A
  • Binds ulcer base

- Ulcers/ Travellers Diarrhea

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6
Q

Misoprostol:

  • MOA?
  • Use?
  • SE? (2)
A
  • PGE1 analog
  • NSAID induced peptic ulcers
  • Diarrhea, induced labor
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7
Q

Octreotide:

  • MOA?
  • Use? (4)
  • SE? (3)
A
  • Somatostatin analog
  • Variceal bleeds, VIPoma, Carcinoid, Acromegaly
  • Nausea, cramps, diarrhea
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8
Q

Aluminum Hydroxide:

  • Use?
  • SE? (5)
A
  • Antacid

- hypokalemia, constipation, low phosphate, muscle weakness, osteodytrophy, seizures

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9
Q

Calcium Carbonate:

  • Use?
  • SE? (3)
A
  • Antacid

- hypokalemia, high calcium, rebound acid

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10
Q

Magnesium Hydroxide:

  • Use?
  • SE? (5)
A
  • Antacid

- hypokalemia, diarrhea, hyporeflexia, hypotension, cardiac issues

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11
Q

Polyethylene Glycol:

  • MOA?
  • Use?
  • SE? (3)
A
  • Osmotic laxative
  • Constipation
  • Diarrhea, dehydration, abused by bilumics
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12
Q

Ifliximab:

  • MOA?
  • Use? (5)
  • SE? (3)
A
  • Anti-TNFa
  • Crohns, UC, AS, Psiorisis, RA
  • TB, Fever, Hypotension
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13
Q

Sulfasalazine:

  • MOA?
  • Use? (2)
  • SE? (3)
A
  • Antibiotic and anti-inflammatory; acivated by bacteria
  • UC, Crohns
  • Sulfa drunk rxn, nausea, oligospermia
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14
Q

Odansetron:

  • MOA?
  • Use?
  • SE? (2)
A
  • 5HT3 antag., decrease vagal stim
  • Antiemetic
  • HA, constipation
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15
Q

Metoclopromide:

  • MOA?
  • Use? (2)
  • SE? (3)
A
  • D2 antagonist
  • Prokinetic; increases resting tone
  • Parkinsonian like symptoms, diarrhea, depression
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16
Q

Lispro:

  • Drug type?
  • Action?
  • SE? (2)
A
  • Rapid acting insulin
  • Bind insulin receptor
  • Hypoglycemia, hypersensitivity reaction
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17
Q

Aspart:

  • Drug type?
  • Action?
  • SE? (2)
A
  • Rapid acting insulin
  • Bind insulin receptor
  • Hypoglycemia, hypersensitivity reaction
18
Q

Glulisine:

  • Drug type?
  • Action?
  • SE? (2)
A
  • Rapid acting insulin
  • Bind insulin receptor
  • Hypoglycemia, hypersensitivity reaction
19
Q

Insulin Regular:

- Drug type?

A
  • Short acting
20
Q

Insulin NPH:

- Drug type?

A
  • Intermediate
21
Q

Glargine:

- Drug type?

A
  • Long acting
22
Q

Detemir:

- Drug type?

A
  • Long acting
23
Q
  • Metformin:
  • Drug type?
  • MOA?
  • SE? (2)
A
  • Biguanides
  • Increase peripheral SI
  • Lactic Acidosis in renal failure, GI upset
24
Q

Tolbutamide:

  • Drug Type?
  • MOA?
  • SE? (2)
A
  • First gen Sulfanylurea
  • Close K+ to release insulin
  • Hypoglycemia in renal failure, disulfaram like reaction
25
Q

Chlorpropramide:

  • Drug Type?
  • MOA?
  • SE? (2)
A
  • First gen Sulfanylurea
  • Close K+ to release insulin
  • Hypoglycemia in renal failure, disulfaram like reaction
26
Q

Glyburide:

  • Drug Type?
  • MOA?
  • SE? (2)
A
  • Second gen Sulfanylurea
  • Close K+ to release insulin
  • Hypoglycemia in renal failure
27
Q

Glimepiride:

  • Drug Type?
  • MOA?
  • SE? (2)
A
  • Second gen Sulfanylurea
  • Close K+ to release insulin
  • Hypoglycemia in renal failure
28
Q

Glipizide:

  • Drug Type?
  • MOA?
  • SE? (2)
A
  • Second gen Sulfanylurea
  • Close K+ to release insulin
  • Hypoglycemia in renal failure
29
Q

Pioglitazone:

  • Drug type?
  • MOA?
  • SE? (4)
A
  • TZD
  • Increased periph. SI
  • Weight gain, CHF, Hepatotoxicity, Edema
30
Q

Rosiglitazone:

  • Drug type?
  • MOA?
  • SE? (4)
A
  • TZD
  • Increased periph. SI
  • Weight gain, CHF, Hepatotoxicity, Edema
31
Q

Acarbose:

  • Drug type?
  • MOA?
  • SE?
A
  • a glucosidase inhibitors
  • Inhibit a-glucosidase brush border
  • GI upset
32
Q

Miglitol:

  • Drug type?
  • MOA?
  • SE?
A
  • a glucosidase inhibitors
  • Inhibit a-glucosidase brush border
  • GI upset
33
Q

Polythiourcil:

  • MOA?
  • Clinical use? (2)
  • SE? (3)
A
  • Block TPO for decrease T4 to T3
  • Hyperthyroidism; pregnancy
  • Agranulocytosis, skin rash, hepatotoxicity
34
Q

Methimazole:

  • MOA?
  • Clinical use?
  • SE? (3)
A
  • Block TPO for decrease T4 to T3
  • Hyperthyroidism
  • Agranulocytosis, skin rash, hepatotoxicity
35
Q

Levothyroxine:

  • MOA?
  • Use?
  • SE? (4)
A
  • T4
  • Hypothyroidism
  • Tachy, heat intolerance, tremors, arrythmias
36
Q

Triiodothyronine:

  • MOA?
  • Use?
  • SE? (4)
A
  • T3
  • Hypothyroidism
  • Tachy, heat intolerance, tremors, arrythmias
37
Q

DDAVP:

- Use?

A
  • Central DI
38
Q

Demeclocycline:

  • MOA?
  • Use?
  • SE? (3)
A
  • ADH antagonist
  • SIADH
  • Nephro DI, Photosensitivity, Bone/teeth abnormalitites
39
Q

Quinidine:

  • Drug type?
  • MOA?
  • Use?
  • SE? (5)
A
  • Class 1a sodium channel block
  • Slow conduction (in depol. cells), decrease phase 0 slope, increase threshold for firing, state dependent, hyperkalemia leads to toxicity
  • Increase AP duration, increase effective refractory period, increase QT interval
  • Tinnitus, HA, thrombocytopenia, torsades de pointes due to increased QT interval
40
Q

Procainimide:

  • Drug type?
  • MOA?
  • Use?
  • SE? (5)
A
  • Class 1a sodium channel block
  • Slow conduction (in depol. cells), decrease phase 0 slope, increase threshold for firing, state dependent, hyperkalemia leads to toxicity
  • Increase AP duration, increase effective refractory period, increase QT interval
  • reversible SLE like syndrome, HA, thrombocytopenia, torsades de pointes due to increased QT interval
41
Q

Discopyramide:

  • Drug type?
  • MOA?
  • Use?
  • SE? (5)
A
  • Class 1a sodium channel block
  • Slow conduction (in depol. cells), decrease phase 0 slope, increase threshold for firing, state dependent, hyperkalemia leads to toxicity
  • Increase AP duration, increase effective refractory period, increase QT interval
  • Heart failure, HA, thrombocytopenia, torsades de pointes due to increased QT interval

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