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Gen Path VF > Viral > Flashcards

Viral Flashcards

1
Q

Rinderpest

A

CD150 (SLAM) B-L membrane

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2
Q

Bluetongue

A

Attachment proteins VP2, VP5

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3
Q

Contagious ecthyma

A

F1L attachment protein

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4
Q

Vesicular stomatitis

A

Glycoprotein G for attachment

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5
Q

Foot and Mouth

A

VP1-4 attaches to alpha integrins (VB1, VB3, VB6)

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6
Q

Swine Vesicular Dz and Vesicular Exanthema of Swine

A

VP1-4 attach to ICAM

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7
Q

IBR (bovine herpes-1) (similar for Fe viral rhinotracheitis and Fe calicivirus)

A

Glycoproteins B, C, D bind to herpesvirus entry mediators A, C, B(nectin 1, nectin 2) and heparin sulfate
Encodes viral proteins ICPO and ICP27 that block IFN-B expression

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8
Q

K9 adenovirus I

A

Fiber protein serves as virus capsid protein for attachment

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9
Q

K9 Distemper

A

Attachment: Viral H protein
Fusion: Viral F protein (also leads to syncytia)
Binds to CD150 (SLAM)

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10
Q

Rabies

A

Binds to envelope G proteins on myocytes

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11
Q

EEE, WEE, VEE, WNV

A

Glycoproteins E1, E2

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12
Q

EBV gammaherpes

A

Binds CD21 in B cells; LMP1 mimicks CD40 is exposed on B cell -> B cell proliferation

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13
Q

Feline coronavirus

A

Serotype I: DC-SIGN and not APN is involved in entry process of serotype I FCoV in Monocytes
Serotype II: BOTH DC-SIGN AND APN; binding is mediated by APN and DC-SIGN is either internalization or another step
Intact 3C protein (for non-mutated FCoV) needed for sustainable infection of enterocytes and infectivity to other cats

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14
Q

BRSV (paramyxovirus)

A 
Attachment protein (G)
Fusion protein (F)
Small hydrophobic protein
NS1, NS2: mediate resistance to IFN
recruites WC1.1 and WC1 negative gamma/delta T cells
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15
Q

Swine influenza type A

A

Hemaglutinin (HA): attachment, internalization, and intracellular fusion of virus
Neuraminidase (NA): prevents aggregation of viral progeny upon release
Polymerase (PA, PB-1, and PB-2): directs cell processes towards replication PB-2 is MOST important, takes pieces of host pre-mRNA; polymerases repsonsible for cross-species infxn
NS1: only in host cell cytosolo, interferes with host response

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16
Q

BVDV

A

Erns protein is expressed in the development of PI calves

17
Q

Malignant Catarrhal Fever

A

15-A antigen epitope defines MCF

ORF25 transcripts are an index of lytic viral gene expression

18
Q

PRRS

A

Sialoadhesins

CD163

19
Q

Canine parainfluenza

A

Targets ciliated mucosal cells
Enters via HN and F glycoproteins
Bordetella most often follows

20
Q

Ovine progressive pneumonia (lentivirus) or CAEV

A

targets cells that express small ruminant lentivirus receptors A or B
Virus infects cells of monocyte macrophage system but ONLY replicates in activated MO in tissues

21
Q

Classical Swine Fever (Hog Cholera, Pestivirus)

A

Erns and E2 envelope glycoproteins involved in binding to tonsillar mucosa (note these are the same as BVDV, another pestivirus)

22
Q

African Swine Fever (asfivirus)

A

Glycoproteins p12, p54, p30 for attachment and binding to host cells

23
Q

African Horse Sickness (orbivirus)

A

VP2 and VP5 (similar to Bluetongue, another orbivirus)

NS3, a viral protein inserted into host cell membrane is a viroporin (alters permeability of cell)

24
Q

Equine Infectious Anemia (EIA virus)

A

Virus express glycoprotein gp90 that binds to equine lentivirus receptor-1 on Mono and MO
Free virus attaches to RBCs->phagocytosis and complement->anemia from IV and EV hemolysis

25
Q

Bovine Leukosis Virus (deltaretrovirus)

A

Malignant transformation of B cells
Virus uses BLV envelope glycoproteins (gp51, gp30) to enter naive B cell that express BLV-binding receptor (those expressing IgM, CD5, CD11b are MORE susceptible)
GENE TRANSACTIVATION integrates viral genome into B cell DNA
Genes of BLV express BLX tax protein (p34tax) that stimulates B cell proliferation

26
Q

FeLV

A

B cells spread virus while T cells are primary target
Four subgroups: FeLV-A spread through saliva->immunosuppression; FeTHTR1 receptor on T cells
FeLV-B: neoplastic transformation; FePit1 or 2 receptor
FeLV-C: anemia; FeLVCR receptor
FeLV-T: infects T cells; FePit1 for receptor and FeLIX secreted by T cells determines tropism
FOCMA antigen is expressed on TRANSFORMED cells ONLY

27
Q

FIV (lentivirus)

A

Target cells express CD134 receptor and CXCR4 cofactor

28
Q

PCV-2

A

Attaches to glycosaminoglycan receptors, heparin sulfate, and chondroitin sulfate B on MO, DC, LO

29
Q

Papillomavirus

A

Capsid proteins (L1 major and L2 minor)

Gen Path VF (4 decks)

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