Bacteria

Question 1

ETEC

Answer 1

K99 (F5) or F41 fimbriae; LT and ST

Question 2

EPEC

Answer 2

Fimbriae
EspA/B/D
Tir and intimin form pedestal

Question 3

EHEC

Answer 3

Shiga or verotoxin

Binds to host cell Gb3

Question 4

Bacillus anthracis

Answer 4

B toxin: protective antigen binds to TEM8 and CMG2

A toxin: Edema or Lethal factor

Question 5

Salmonellosis

Answer 5

Type III SS leads to phagocytosis by M cell

Kills MO by TISS to activate caspase 1

Question 6

C perfringens

Answer 6

Alpha and beta toxins: pore formers
Epsilon: targets enterocytes and endothelial cells and attacks cytoskeleton
Iota: targets cytoskeleton and leads to cell death

Question 7

C perf type A

Answer 7

NetB: pore former from NELoc-1 on plasmid
NELoc3: codes for hydroxysteroid hydrogenase that degrades bile acids
NELoc2: encodes cell wall and membrane factors; only one on CHROMOSOME, not plasmid

Question 8

Yersinia

Answer 8

Yop that encodes TIIISS, injects Yop E, H, T to block phagocytosis and Yop J that inhibits cytokines

Question 9

Johnes (MaP)

Answer 9

ManLAM
Exochelins, iron reductases, siderophores
Peroxidase prdxn to block phago-lyso fusion

Question 10

C hemolyticum

Answer 10

Phospholipase C and hemolysins

After fluke migration

Question 11

C novyi

Answer 11

PLC

Question 12

Mycoplasma hyopneumoniae

Answer 12

Cilium adhesin

Question 13

Atrophic rhinitis

Answer 13

B bronchiseptica: Dermonecrotic toxin, adenylate cyclase hemolysin, outer membrane protein pertactin
P multocida: PMT

Question 14

Mannheimia

Answer 14

Leukotoxin (LKT-A) which binds to CD18

Neuraminidase to digest mucus

Question 15

Actinobacillus pleuropneumoniae

Answer 15

Scavenge iron from porcine transferrin and lysed RBCs
Capsule
LPS
Apx I-III toxin (RTX toxin family) prevents phagocytosis

Question 16

Rhodococcus equi

Answer 16

Capsule
PLC
Virulence associated protein (VAP)

Question 17

Pseudomonas

Answer 17

A-B exotoxin called exotoxin A targes ribosomal protein EF-2
Alginate secretes biofilm
Produces N-acyl homoserine lactone and inhibits I-kB to interfere with NF-kB

Question 18

M tuberculosis

Answer 18

Phthiocerol dimycocersoerate to hide PAMPs

Question 19

Leptospirosis

Answer 19

Motility

Len family of adhesion molecules

Question 20

Burkholderia mallei

Answer 20

Type I O-antigenic polysaccharide antigen and Type IV pili

Question 21

Uropathogenic E coli

Answer 21

Type 1, P, & S fimbriae

Type 1 express FimH adhesin

Question 22

Strep equi equi

Answer 22

Hyaluronic acid, SeM, Se18.9 inhibits phagocytosis

Streptolysin S kills WBCs

Question 23

Corynebacterium pseudotuberculosis

Answer 23

Phospholipase D

Question 24

Borrelia burgdorferi

Answer 24

VlgE surface protein

Question 25

Listeria monocytogenes

Answer 25

Internalins to enter cell
Surface protein ActA propels into adjacent cell
Listeriolysin O inhibits immune response

Question 26

C chauvoei

Answer 26

Alpha and beta toxins: hemolysin, DNase, neuraminidase

Question 27

S aureus

Answer 27

A and B toxin: cleave desmoglein I
protein A: binds Ig to deactivate them
Alpha toxin: forms pores
Beta toxin: sphingomyelinase
Delta toxin: detergent
Gamma toxin: lyse RBCs and phagocytes
Superantigens: Toxic shock (with Strep pyogenes)

Question 28

Strep pyogenes

Answer 28

Superantigen for toxic shock syndrome

M protein to reduce complement

Question 29

Lawsonia intracellularis

Answer 29

Cell proliferation induced by cyclomodulin produced by Rho family proteins which act on E2F to drive cell cycle