Vestibular Diseases Flashcards

1
Q

What is the main function of the vestibular system?

A
  1. maintain balance
  2. maintain position of the eyes, neck, limbs and trunk relative to the position or motion of the head

deviations in the vestibular system will affect these functions

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2
Q

What bone is the peripheral vestibular system in?

A

petrous temporal bone

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3
Q

What is bony labyrinth filled with?

A

Perilymph

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4
Q

What is the membranous labyrinth filled with?

A

Endolymph

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5
Q

Nystagmus fast phase is toward the Normal or Diseased side?

A

Fast Phase toward NORMAL side

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6
Q

Crista ampullaris is important for what kind of equilibrium?

A

Dynamic

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7
Q

Maculae and saccule are important for what kind of equilibrium?

A

Static

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8
Q

Peripheral Vestib. head tilt

A

side of lesion

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9
Q

Central vestib head tilt

A

usually toward side of lesion but can be paradoxical and go other side

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10
Q

Peripheral vestib nystagmus

A

horizontal or rotary

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11
Q

Central vestib nystagmus

A
  • vertical* is always central

* positional* and changing from any of them

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12
Q

Peripheral vestib postural reactions

A

no deficits

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13
Q

Central vestib postural reactions

A

on side of lesion

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14
Q

CN Deficits peripheral vestib

A

ipsilateral +/- CN 7 since they run together peripherally

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15
Q

CN deficits central vestib

A

ispsilateral CN 5-8

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16
Q

Can Horner’s be present in either peripheral or central?

A

yes

17
Q

Consciousness affected by peripheral or central vestib?

A

not peripheral

central can be normal to comatose

18
Q

If an animal looks funky and is making WIDE HEAD movements what does that indicate?

A

they cannot move their eyes, can be two things

  1. bilateral peripheral vestib dz
  2. blind

CANNOT BE CENTRAL, animal would be comatose if there was a bilateral central lesion in the medulla

19
Q

With Paradoxical Central Vestib. Dz, what side is the lesion on?

A

side of the postural reaction deficits

20
Q

How can you tell from a distance if disease is central or peripheral?

A

Head tilt, nystagmus, or vestibular ataxia

21
Q

How do you pursue diagnostics once you discern the lesion is central?

A

CBC/Chem/UA/T4/BP then follow up with MRI if that’s not definitive enough

22
Q

How do you pursue diagnostics once you discern the lesion is peripheral?

A

straight to the Otoscopic exam**
if normal –> Tympanic Bullae imaging Rads/US/CT/MRI
if abnormal –> Fluid cytology or mass aspirate

If normal and imaging normal –> Thyroid profile

23
Q

Peripheral vestibular diseases DDX

A

Anomalous: congenital disease
Metabolic: Hypothyroid dog
Neoplastic: 1˚ Aural, Nerve Sheath or Osteosarcoma
Inflammatory: Otitis Media Interna, nasopharyngeal polyp, idiopathic
Toxic: drugs, almost everything is toxic but don’t realy get that bad of responses to most things

24
Q

What would make you think Anomalous peripheral vestib. dz?

A

Age: young
Malformation or early onset abiotrophy

No therapy

25
Q

What would make you think Metabolic peripheral vestib. dz?

A

Other clinical signs of hypothyroidism:
- alopecia, loss of hair, obtunded and dull look/mentation

Pathophys: Myxomatous compression of nerves, dec. inner ear perfusion, axonal transport defects

Dx: T4 fT4, TSH

Tx: Levothyroxine supplement (give thyroid hormone/analog)
- Will improve in days to months

26
Q

What would make you think of Neoplastic peripheral vestib. dz?

A

Mass in the ear
DX: mass in ear and evidence of bony lysis/infiltration on imaging
TX: Sx is primary therapy; +/- radiotherapy; if lymphoma chemo +/- radio

27
Q

Cat or dog more concerning to have aural tumor?

A

Cats are 85% malignant - SCC

Dogs only 60% malignant - carcinoma

28
Q

What would make you think inflammatory cause of peripheral vestib. dz?

A

Head-shaking, pawing at ear, exudate, redness, pain at ear
bulging, opaque tympanic membrane
concurrent facial paresis

TX: Anesthesia, deep cleaning and Systemic antibiotics based on C/S
- get all underlying factors under control

29
Q

What would make you think idiopathic cause of peripheral vestib. dz?

A

Old dog - 12y and up, rarely in dogs < 5yo
Any age of cats can be affected though, more common in outdoor and late summer, early fall

DX: rule out other causes
TX: supportive care and physical therapy, clinical improvement in 2 weeks, head tilt may remain

30
Q

What are the main culprits of Central Vestib Dz?

A

Meningoencephalitis, neoplasia and Stroke account for 80% of central vestib dz. in Adult Dogs

recognition of central dz is grounds for immediate advanced imaging

31
Q

How many peripheral vestib cases have OMI?

A

50%

32
Q

How many chronic cases of otitis Externa have OMI?

A

50%

33
Q

How many OMI cases have otitis Externa?

A

80%

34
Q

DDX of central vestib dz:

A

Metabolic: Hypothyroidism
Neoplastic: Meningioma, Choroid plexus tumor, glioma
Inflammatory: Meningoencephalitis (Distemper, FIP, Protozoal, RMSF); otogenic infections, Granulomatous Meningoencephalitis
Toxic: Metronidazole
Vascular: Infarcts, Transient ischemic attacks

35
Q

What would make you think metabolic cause of central vestib?

A

accompanying signs of hypothyroidism

36
Q

What would make you think neoplastic cause of central vestib?

A

focal central lesion neurolocalization and evidence on CT/MRI

37
Q

What would make you suspect toxic cause of central vestib?

A

History of metronidazole
TX: stop drug (improve 4-12 days); give antidote if necessary Diazepam (improvement 12-48 hr)

Rule out metronidazole tox by giving diazepam and seeing if central vestib signs go away

38
Q

What is a transient ischemic attack?

A

Lasts less than 24 hours by definition. caused by vasospasm or stenosis

To rule out screen for strokes: hypertension, atherosclerosis, and coagulopathies

39
Q

What is pathophys of hypothyroidism causing central/peripheral acute/chronic vestib signs?

A
  • atherosclerotic cerebrovascular disease – predisposes to stroke
  • dec. axonal transport in brainstem white matter