vesicular trafficking

Question 1

examples of GTPases

Answer 1

Rho, Ras, Arf, Rab

Question 2

role of GTPases

Answer 2

molecular switches or timers in many fundamental cellular processes. Examples of these roles include: Signal transduction in response to activation of cell surface receptors, including transmembrane receptors such as those mediating taste, smell and vision.

Question 3

how are GTPases switched on and off

Answer 3

GEF turns on

GAP turns off

Question 4

where are the two forms of GTPases found

Answer 4

GDP form usually in the cytosol

GTP form is membrane associa

Question 5

COPII components

Answer 5

GTPase: Sar 1
Adaptor: Sec23/24
Coat: Sec 13/31

Question 6

what is AP2

Answer 6

major clathrin adaptor, selects material from outside of cell - endocytosis

Question 7

what are adaptor proteins, role

Answer 7

Recognise and select cargo ensuring specificity

Adaptors recognise motifs in the cytoplasmic domains
of membrane proteins

Question 8

role of protein coat

Answer 8

Coat proteins provide a structural scaffold