Cell Cycle Flashcards
What two factors determine cell fate
Proliferation and quiscence
What cdks and cyclins are in g1
CDK4 AND 6 cyclins D
What cdks and cyclins at r point
E type cyclins and cdk2
What cdks and cyclins at S phase
A type cyclins and cdk2 then later cdc2
What cyclins and cdks are at G2 phase
B cyclins and cdc2
What cdks and cyclins are at the M phase
Cdc2 and b type
What cdks you are at G0 phase
Cyclin c and cdk3
What are the two control factors in cell cycle
Cyclins drive forward
Checkpoints stop cylce
What happens when cyclins no longer in use
Different cyclins are most prevelant at diff stages. Ubiquitination occurs to collapse levels
Why are D type cyclins special
Are extracellular signals all other are intracellular. Are controlled by growth factor and ECM integrin
What regulated cyclin cdks
Cdk Inhibitors
What is checked at Checkpoint 1 in G1
Non homologous ends, DNA damage, environment suitable
What so checked at Checkpoint 2 G2
Homologous recombination, DNA replicated, size of cell, damag
What occurs if notice DNA damage
ATM/ATR get activated and associate with site of damage. Turn on p53 which turns on p21 which is a CKI and stops G1 to S CDK
{what occurs in G1
Inactive helicases bind to origin od replication and for PreRC - this is called licensing and only occurs once in a cycle
