Vesicular trafficking 2 Flashcards
1
Q
What GTPase is associated with COP2
A
Sar1
2
Q
What is the COP2 adaptor protein
A
Sar23/24
3
Q
COP2 coat?
A
Sar13/31
4
Q
Why are adaptor proteins important?
A
Selecting and recognising cargo (specificity)
5
Q
What is a major clathrin adaptor?
A
AP2
6
Q
WHAT DO COAT PROTEINS PROVIDE?
A
strucural scaffold
7
Q
What do adaptor proteins recognise?
A
Cytoplasmic motifs
8
Q
How did they know theyd vesicles in reconstitution experiments?
A
P58 but no ribosphorin which is found in ER membranes
9
Q
- What is cranial-lenticulo-sutural dysplasia caused by?
A
SEC23A mutation causing abnormal ER golgi trafficking
- Open fontanel
- Autosomal recessive?
10
Q
- What does the ER of mutant show?
A
Dilation of ER
11
Q
- What mutation causes this disease?
A
Single base substation
