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Cell + Molec > GPCRs > Flashcards

GPCRs Flashcards

1
Q

What are the effectors of the Gq protein?

A

Activates phospholipase C to produce IP3 releasing Ca2+

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2
Q

What does phospholipase C do?

A

Cleaves PIP2 to make IP3 and diacylglycerol

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3
Q

What is diacylglycerol?

A

Hydrophobic messenger generated by PIP2 cleavage

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4
Q

What does phopholipase D create?

A

Phosphatidic acid

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5
Q

What does calmodulin phosphorylase kinase activate?

A

Phosphorylase P

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6
Q

What is the negative feedback loop in Gs system?

A

Prolonged stim. of B2 adreno pathway - BAR phosphorylates residues and B arestin stops signalling

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7
Q

What 2nd messenger is created by phospholipase A2?

A

Arachidonic acid

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8
Q

What does DAG regulate?

A

Protein kinase C family

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9
Q

Where are IP3 receptors found?

A

ER

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10
Q

How is IC Ca2+ kept so low?

A

Ca2+ ATPase pump

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11
Q

How does PKa amplify signal in Gs?

A

Phosphorylates calmodulin phosphorylase kinase

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Cell + Molec (6 decks)

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