GPCR 1 Flashcards
1
Q
What are PAR receptors activated by?
A
Activated by thrombin a protease and cleaves amino acid to activate receptor
2
Q
What type of receptor is PAR?
A
GPCR
3
Q
What happens to PAR TMs upon agonist binding?
A
TM5+6 move to reveal binding pocket for alpha subunit of heterotrimeric GTP binding protein
4
Q
How do heterotrimeric G proteins become activated?
A
when alpha subunit dissociates GDP==>GTP
5
Q
IN a monomeric G protein what do G proteins associate with?
A
GEF
6
Q
What is speed of activation in heterotrimeric proteins governed by?
A
Rate of GTP hydrolysis by Galpha
7
Q
What proteins stimulate GTPase activity?
A
RGS proteins
8
Q
WHat is cAMP production regulated by?
A
Adenylyl cyclase
9
Q
What is cAMP removed by?
A
phosphodiesterase
10
Q
What type of G protein is RAS?
A
Monomeric
