Venous thromboembolism

Question 1

Venous thromboembolism

Answer 1

The thrombophilias are disorders which promote blood clotting due to an excess
of clotting factors or a deficiency of anticlotting proteins that limit clot formation.
* will develop deep vein thrombosis or venous thromboembolism (VTE) that can
become life-threatening

Question 2

Risk factors include

Answer 2

1. Immobilization
2. surgery
3. pregnancy

Question 3

the leading cause of maternal death in the United
States?

Answer 3

Pulmonary embolus

Question 4

Types of thrombophilias

Answer 4

• Inherited thrombophilias

*Acquired thrombophilias

Question 5

Inherited thrombophilias types :

Answer 5

1. Homozygosity for factor V Leiden (FVL) mutation
2. pro- thrombin gene mutation
3. protein C deficiency
4. protein S deficiency (PSD)
5. antithrombin deficiency (ATD).(most serious )

Question 6

Acquired thrombophilias

Answer 6

antiphospholipid syndrome (APS

Question 7

antiphospholipid syndrome (APS) diagnosis

Answer 7

One or more of the following three antiphospholipid antibodies must be positive on ≥2
occasions at least 12 weeks apart.

*– Lupus anticoagulant
*– Anticardiolipin antibody (lgG & IgM)
*– Anti-β2-glycoprotein 1 (lgG & IgM)

Question 8

Give anticoagulant in case of

Answer 8

**antithrombin deficiency

**Homozygosity for factor V Leiden (FVL) mutation

**HX of thrombosis+ heterozygosity for Prothrombin gene mutation

**HX of thrombosis + heterozygosity for FVL mutation

**compound heterozygosity Prothrombin gene mutation + FVL mutation

Question 9

anticoagulants in pregnancy

Answer 9

LMWH (from the diagnosis to 6-12 weeks after delivery )

Question 10

if she had DVT after delivery

Answer 10

give anticoagulant 3-6 months

Question 11

the most sensitive test for diagnosis of pulmonary embolism

Answer 11

spiral CT