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Sketchy Micro > +ve sense RNA Viruses > Flashcards

+ve sense RNA Viruses Flashcards

1
Q

Flavi viruses and diseases

A

Hep c , dengue fever , yellow fever , West Nile virus

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2
Q

Dengue fever symptoms

A

Thrombocytopenia , hemorrhagic fever , renal failure

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3
Q

Dengue fever other name is

A

Break bone fever

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4
Q

Yellow fever symptoms

A

Jaundice , Back ache , bloody stool , black vomitus

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5
Q

Yellow fever has

A

Live attenuated vaccine

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6
Q

West Nile virus symptoms

A

Encephalitis , meningitis , seizures

Flaccid paralysis , coma

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7
Q

Hepatitis C is a member of

A

Flavivirus family

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8
Q

Hepatitis C transmission

A

Blood transfusion , needle sharing or sticks, placental , breast feeding and sex

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9
Q

Hepatitis C show ,,,,,,,

A

Antigenic variability of enveloped proteins

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10
Q

Antigenic variability of hep C due to

A

No proofreading of 3-5exonuclease activity

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11
Q

Hep C outcomes

A

Cirrhosis

Hepatocellular carcinoma

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12
Q

During acute infection of Hep C

A

ALT will rise and fall by 6 months

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13
Q

Hep C associated with

A

Cryoglobulins

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14
Q

Hep C treatment

A

Ribavirin + interferon alpha

Protease inhibitors

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15
Q

Picorna family transmitted by

A

Feco-oral route “except Rhino virus”

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16
Q

Picorna family include

A

Hepatitis A , Enteroviruses , Rhinovirus

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17
Q

Enteroviruses include

A

Poliovirus , Coxsackie A and B , Echovirus

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18
Q

Enteroviruses are the number one cause of

A

Aseptic meningitis (CSF glucose normal , No organisms , elevated protein) , children are at high risk

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19
Q

Rhinovirus is acid ……..

A

Labile

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20
Q

Rhinovirus transmitted by

A

Fomites أدوات معدية or contaminated hand of respiratory secretions

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21
Q

Rhinovirus enter the host cell by

A

Attachment to ICAM-1

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22
Q

Rhinovirus grow best at

A

Cooler temperature (around 33c)

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23
Q

Rhinovirus cause

A

URI

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24
Q

Rhinovirus has different

A

many serotypes

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25
Q

Hepatitis A is acid ……..

A

Stable

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26
Q

Picorna family are

A

Naked viruses

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27
Q

Picorna family

A

Produce one long polyprotein cleaved by viral protease

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29
Q

Hepatitis A transmitted by

A

Feco-orally and contaminated water , shellfish in developing countries

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30
Q

Hepatitis A commonly seen in

A

Travelers to endemic areas

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31
Q

Hepatitis A cause

A

Jaundice is adults , acute anecteric hepatitis in infants and young children

32
Q

Smokers with Hepatitis A develop

A

Aversion (كره) to smoking

33
Q

Notes about Hep A

A

One month only of symptoms
Self limiting
No carrier

34
Q

Inactivated vaccine for

A

Hep A

35
Q

Poliovirus is ………………. and transmitted by

A

Acid stable , feco-oral route

36
Q

Replication of polio occurs in

A

Peyer’s patches

37
Q

Poliovirus affect

A

The anterior horn of spinal cord

38
Q

Poliovirus symptoms

A

Asymmetric paralysis , respiratory insufficiency , viral meningitis

39
Q

Polio vaccines

A

Oral Sabin (live attenuated ), injectable Salk (killed)

40
Q

Oral Sabin vaccine create

A

IgA response

41
Q

Coxsackie A associated with

A

Hand , foot and mouth disease(Red vesicular rash), aseptic meningitis

42
Q

Coxsackie A infection common in

A

Summer months

43
Q

Coxsackie B cause

A
  1. Dilated cardiomyopathy

2. Devils grip(Bornholms disease/pleurodynia)

44
Q

Calicivirus is

A

Naked virus

45
Q

The most common calicivirus is

A

Norovirus

46
Q

Norovirus outbreaks common in

A

Daycare centers and schools

47
Q

Consumption of shellfish is associated with

A

Norovirus infection

48
Q

Norovirus cause

A

Explosive watery diarrhea

49
Q

Calicivirus produce

A

One long polyprotein cleaved by viral protease

50
Q

Togavirus has two types

A

Arbovirus , Rubella virus

51
Q

Arbovirus subtypes

A

Western , eastern and Venezuelan

52
Q

Arbovirus cause

A

Encephalitis

53
Q

Rubella Childhood exanthem “skin rash” it’s symptoms :

A

.Postaurciular and occipital lymphadenopathy
.Rash starts at the head and move downward
(Move Faster than measles)

54
Q

Rubella transmission via

A

Respiratory droplets

55
Q

Congenital rubella classic triad:

A
  1. patent ductus arteriosus
  2. congenital cataract
  3. sensory-neural deafness
56
Q

Other congenital rubella symptoms :

A

Blueberry muffin rash , Jaundice

57
Q

Adult rubella cause

A

Polyarthritis

58
Q

HIV positive patients should receive MMR vaccine only when

A

CD4 count above 200

59
Q

Like picorna , Togavirus produce

A

One long polyprotein that cleaved by viral protease

60
Q

Big Buzzword(key word ) about Rubella infection

A

Immigrant

61
Q

Rubella other name

A

German measles

62
Q

Diploid RNA positive virus is

A

Retro virus

63
Q

Gag gene make

A

P24 , which is the capsule for RNA strands

64
Q

Env gene make

A

Gp120 surface protein and Gp41 transmembrane protein

65
Q

HIV one of the ………… infection

A

TORCHES

66
Q

HIV initially infect

A

Macrophages

67
Q

HIV infections first symptoms

A

Flu or mono-like symptoms , lymphadenopathy

68
Q

AIDS diagnosed when

A

CD4+ cells <200

69
Q

HIV associated disease

A

Diffuse large B cell lymphoma

70
Q

HIV gains entry via

A

CCR5 in early stages and CXCR4 in late stages

71
Q

Screening test for HIV by………… and confirmation done with…………..

A

ELISA test , western blot

72
Q

HAART

A

NRTIs (nucleotide reverse transcriptase inhibitors )like zidovudine for pregnant patients.
NNRTIs(non-nucleotide reverse transcriptase inhibitors)
Protease inhibitors
CCR5 inhibitors like Maraviroc

73
Q

Corona virus is

A

Helical Encapsulated +ve sense RNA virus

74
Q

Corona virus cause

A

Common cold

Acute bronchitis can lead to acute respiratory distress syndrome

Sketchy Micro (3 decks)

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