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Sketchy Micro > -ve RNA Viruses > Flashcards

-ve RNA Viruses Flashcards

1
Q

Measles

A

Causes 4c “cough , coryza , conjuctivits , koplick spots

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2
Q

Measles complications

A
  1. pneumonia

2. SSPE “subacute sclresonig pan-encephalitis “

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3
Q

Measles virulence factors

A

HA , fusion protein

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4
Q

Reduce measles mortality

A

Vitamin A

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5
Q

Mumps sings and symptoms

A

Parotitis , orchitis , meningitis

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6
Q

Mumps virulence factors

A

HA , fusion protein , NA

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7
Q

Live attenuated MMR vaccine

A

Contraindicated in pregnancy

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8
Q

Rash of measles

A

Start on the face and spread downwards

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9
Q

RSV mechanism of infection

A

Attach to G protein

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10
Q

The most common cause of bronchiolitis and pneumonia in infants

A

RSV

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11
Q

RSV virulence factor

A

Fusion protein

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12
Q

Treatment of RSV

A

Ribavirin

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13
Q

Prevention of RSV

A

Palivizumab

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14
Q

Parainfluenza symptoms and signs

A

Seal bark cough , steeple sign on x-ray , croup”laryngotracheobrochitis” , inspiratory stridor .

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15
Q

Parainfiluenzae virus virulence factors

A

HA , fusion protein , NA

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16
Q

Bonya virus is

A

Enveloped “ obtained from the Golgi body of host cells

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17
Q

Bonya virus has

A

3 circular segments

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18
Q

Bonya viruses species

A

Arbovirus , Hantavirus, California encephalitis virus , Rift Valley fever virus

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19
Q

Hantavirus reservoir

A

Deer mouse

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20
Q

Hantavirus transmitted by

A

Rodent urine/feces

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21
Q

Hantavirus cause

A

Pulmonary Edema
Prerenal azotemia
Hemorrhagic fever

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22
Q

California encephalitis virus , Rift Valley fever virus transmitted by

A

Aedes mosquito

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23
Q

Arenavirus characters

A

Enveloped -ve sense RNA
Ambisene
Heclical
Has 2 segments

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24
Q

Virus has garnular appearance on microscopy is

A

Arenavirus

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25
Q

Arenavirus transmission by

A

Rodents

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26
Q

LCV lymphocytic choriomeningitis virus is a member of

A

Arenavirus

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27
Q

LCV cause

A

Meningoencephalitis

Fever

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28
Q

Arenavirus inactivated by

A

Heat

Irradiation

29
Q

Reovirus is

A

Naked double stranded RNA virus

30
Q

The segmented viruses are

A

BOAR “ Bonya , Orthomyxo , Arena , Reo” viruses

31
Q

Reovirus has ………….. segments

A

11

32
Q

Rotavirus is a member of

A

Reovirus family

33
Q

Rotavirus cause

A

Watery diarrhea by NSP4 toxin

34
Q

NSP4 toxin increase

A

Chloride permeability

35
Q

………….. are at risk for rotavirus infection

A

Children

36
Q

The number one cause of severe diarrhea in young children is

A

Rotavirus

37
Q

Colorado tick virus is a member of

A

Reovirus family

38
Q

Colorado tick virus cause

A

Fever , myalgia , vomiting

39
Q

Rotavirus oral live attenuated vaccine side effect is

A

Intussusception (telescoping of the bowel)

40
Q

All RNA viruses replicate inside

A

The cytoplasm except orthomyxovirus (inside the nucleus)

41
Q

Orthomyxoviruses include

A

Infeluenza A , B and C

42
Q

Orthomyxovirus has ………… segments , which allow for ………….

A

8 , antigenic variation

43
Q

………………. is point mutation in the viral genome of orthomyxovirus

A

Antigenic drift

44
Q

…………………. is when segments are shared to form a new species

A

Antigenic shift

45
Q

Antigenic shift responsible for

A

Pandemics

46
Q

Antigenic drift responsible for

A

Seasonal flu or epidemics

47
Q

influenza viruses – A causes……………………..

– B causes…………………

A

epidemics and pandemics (Antigenic shift), epidemics (antigenic drift)

48
Q

Orthomyxovirus pathogenesis by

A

Hemagluttinin and neuroaminidase

49
Q

Hemagluttinin bind to

A

sialic acid promoting viral entry

50
Q

Neuroaminidase cleaves

A

sialic acid to release virions from host cell (promotes progeny virion release)

51
Q

HA molecule will bind to sialic acid on the cell membrane, then endocytosed into the cell, pH needs to be changed by ………………. to allow for uncoating.

A

M2 protein

52
Q

M2 protein inhibitors

A

Amantadine/Rimantadine (no uncoating)

53
Q

Neuroaminidase inhibitors

A

Oseltamivir/Anamivir (inhibit virion release)

54
Q

Infeluenza transmission via

A

Respiratory droplets

55
Q

Infeluenza has two vaccines

A

Injectable killed and intranasal live attenuated

56
Q

A major complication for infeluenza

A

Pneumonia

57
Q

…………… is contraindicated in children with viral illness

A

Aspirin cause Reye syndrome ( encephalitis and hepatomegaly )

58
Q

Infeluenza associated with

A

Guillain-Barré syndrome (ascending paralysis)

59
Q

Filovirus is

A

Enveloped helical -ve sense RNA virus

60
Q

Viruses of Filovirus family

A

Ebola and Marburg viruses

61
Q

Filoviruses can cause

A

Fever , Petechial rash can progress to hemorrhagic fever , end-organ failure and shock

62
Q

Filovirus transmission

A

Through infected bats or primates (monkeys)

63
Q

Bullet shapd virus is

A

Rhabdovirus

64
Q

Carriers of rabies

A

Bats ,Foxes skunks and other rodents

65
Q

Rhabdovirus pathogenesis

A

binds by its glycoprotein spikes to nicotinic acetylcholine

receptors in postsynaptic membrane of motor endplate

66
Q

Rabies symptoms

A

Fever , encephalitis , hydrophobia

67
Q

Rabies diagnosis

A

Negri bodies (eosinophillic cytoplasmic inclusions ) found in hippocampal pyramidal cells and purkinje cells of cerebellum.

68
Q

Rabies treatment

A

Postexposure prophylaxis is wound cleaning plus immunization with killed vaccine and rabies immunoglobulin

Sketchy Micro (3 decks)

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