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DNA Viruses Flashcards

1
Q

Parvovirus is

A

Naked single stranded DNA virus

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2
Q

The smallest DNA virus is

A

Parvovirus

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3
Q

Parvovirus transmission through

A

Respiratory droplets

Vertical transmission

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4
Q

Parvovirus B19 cause in children

A

Slapped cheek fever aka fifth disease

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5
Q

Parvovirus rash , erythema infectiosum

A

raised, indurated rash Start on the face and move downward

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6
Q

Parvovirus B19 cause in adults

A
  1. Joint pain , arthritis and edema

2. Aplastic anemia

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7
Q

Parvovirus B 19 in fetus cause

A

severe anemia, CHF, hydrops fetalis; spontaneous abortions

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8
Q

Polyomavirus is

A

Naked Circular double stranded DNA virus

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9
Q

Polyomavirus JC causes

A

PML Progressive multifocal leukoencephalopathy

Occur mainly in AIDS or immunocompromised patients with CD4 count <200.

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10
Q

Progressive multifocal leukoencephalopathy cause demyelination leads to

A

non-enhancing multifocal brain lesions in white matter

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11
Q

POLYOMAVIRUS BK causes

A

Nephropathy particularly in transplant patients, hemorrhagic cystitis

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12
Q

Parvovirus is

A

Naked single stranded DNA virus

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13
Q

The smallest DNA virus is

A

Parvovirus

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14
Q

Parvovirus transmission through

A

Respiratory droplets

Vertical transmission

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15
Q

Parvovirus B19 cause in children

A

Slapped cheek fever aka fifth disease

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16
Q

POLYOMAVIRUS BK causes

A

Nephropathy particularly in transplant patients, hemorrhagic cystitis

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17
Q

Progressive multifocal leukoencephalopathy cause demyelination leads to

A

non-enhancing multifocal brain lesions in white matter

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18
Q

Polyomavirus JC causes

A

PML Progressive multifocal leukoencephalopathy

Occur mainly in AIDS or immunocompromised patients with CD4 count <200.

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19
Q

Polyomavirus is

A

Naked Circular double stranded DNA virus

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20
Q

Parvovirus B 19 in fetus cause

A

severe anemia, CHF, hydrops fetalis; spontaneous abortions

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21
Q

Parvovirus B19 cause in adults

A
  1. Joint pain , arthritis and edema

2. Aplastic anemia

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22
Q

Parvovirus rash , erythema infectiosum

A

raised, indurated rash Start on the face and move downward

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23
Q

HPV is

A

Naked DNA virus

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24
Q

HPV 1-4 associated with

A

Verruca vulgaris = cutaneous common wart

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25
HPV 6 and 11 associated with
1. Laryngeal papillomas aka recurrent respiratory papillomatosis 2. anogenital warts aka Condylomata acuminate
26
HPV 16 ,18, 31 , 33 associated with
Anogenital cancers
27
Guardasil vaccine
inactivated subunit vaccine covers serotypes 6, 11, 16, and 18
28
HPV malignancy pathogenesis
- E6 inhibits tumor-suppressor gene p53 | - E7 inhibits tumor-suppressor gene Rb
29
Pap smear
screening of cervical cancer (finding of koilocytic cells)
30
• Is an AIDS-defining illness; ....................... increases the risk of HPV-related cancers
immunosuppression
31
HSV is
Enveloped dsDNA and linear virus
32
``` Cowdry bodies (intranuclear inclusion bodies) Associated with ```
HSV
33
HSV transmission
Sexual , vertical
34
HSV1 cause
Gingiovostomatitis Cold sore (Herpes labialis) Keratoconjunctivitis(serpiginous corneal ulcers on fluorescein slit lamp exam seen) Erythema Multiform may appear 1-2 weeks after infection
35
HSV1 latent in
Trigeminal ganglia
36
Herpes rash has
“dew on rose petals” appearance
37
Herpetic Whitlow
Herpes rash on the fingers, more common in dentists
38
HSV2 infection cause
Painful inguinal lymphadenopathy | Aseptic meningitis in adolescents & adults
39
HSV2 lies dormant in
Sacral ganglia
40
Tzanck test
a smear of an opened skin vesicle to detect multinucleated | giant cells commonly seen in HSV-1, HSV-2, and VZV infection
41
Herpes treatment
Acyclovir
42
Varicella zoster virus is
Enveloped dsDNA (a member of Herpes family)
43
1ry infection of VZV
Chicken pox
44
VZV transmission
Respiratory droplets , vertical (TORCH)
45
Adult presentation of chickenpox is with
pneumonia and encephalitis; occurs especially in immunocompromised patients
46
Vaccine of varicella zoster is
Live attenuated vaccine for children
47
VZV treatment
Acyclovir , Famcyclovir and Valacyclovir
48
VZV remains latent in
Dorsal root ganglia
49
Reactivation of VZV occur with
Stress , aging and immune compromised state
50
Reactivated form of VZV infection is called
Shingles aka Herpes Zoster
51
Herpes zoster or Shingles present with
painful vesicles that have “dew drops of rose petals” | appearance to one dermatome
52
Post-Herpatic Neuralgia
the pain that results after the rash subsides and persists for months.
53
Herpes Zoster Opthalmicus
vision loss is possible when CN V1 is affected
54
Congenital Varicella Syndrome; presents with
limb hypoplasia, cutaneous dermatomal scarring, and | blindness
55
CMV is a member of ................ family
Herpes
56
CMV remains latent in
mononuclear leukocytes like B and T cells and macrophages
57
CMV transmission
Congenital transfusion(TORCHES), sexual contact
58
Congenital CMV characterized by
``` Blueberry muffin rash Jaundice and hepatosplenomegaly Sensorineural deafness Periventricular calcifications Seizures Hydrops fetalis ```
59
.......... is #1 cause of sensorineural hearing loss in children AND congenital viral infection
CMV
60
CMV In a transplanted organ patient or in an AIDS patients it causes
Interstitial pneumonitis
61
In AIDS patients , CMV causes
retinitis Esophagitis with linear ulcerations CMV colitis with ulcerated walls
62
Owl-eye inclusion (enlarged cells with basophilic intranuclear and intracytoplasmic inclusions ) seen with
CMV infection
63
CMV treatment
ganciclovir or foscarnet with human immunoglobulin In patients who are Resistance to ganciclovir is through UL97 gene
64
CMV in Children and Adults causes
Mononucleosis (fever, fatigue, splenomegally and atypical lymphocytosis)
65
EBV primarily transmitted through
Saliva aka ''kissing disease"
66
EBV causes kissing disease that presents with
Fever pharyngitis and tonsillar exudates Tender lymphadenopathy hepatosplenomegaly
67
atypical reactive CD8+ cytotoxic T cells, aka Downey Cells; seen on blood smear is seen with
EBV infection
68
EBV remains latent in
B cells
69
EBV envelope glycoprotein bind ................. to infect B cells
CD21
70
If mistakenly given amoxicillin or ampicillin for EBV treatment , can develop characteristic
Maculopapular rash
71
Associated malignancies with EBV
Burkitt Lymphoma Nasopharyngeal carcinoma Hodgkin B Cell Lymphoma of Mixed Cellularity
72
Hodgkin B Cell Lymphoma of Mixed Cellularity diagnosed with
Reed-Sternberg cells that look like | owl eyes
73
African or Endemic form of Burkitt Lymphoma involve
The maxilla or mandible
74
Nasopharyngeal carcinoma: predominately found in
Asian adults
75
Hairy Oral Leukoplakia in AIDS patients
A non cancerous lesion that occur with EBV infection
76
Diagnosis for EBV infection
Monospot test
77
Patient with mononucleosis should Avoid contact sports until resolution due to
Risk of splenic rapture
78
HHV-6 infects
CD4 T cells
79
Roseola or exanthema subitum is characterized by
Fever generally lasts 4 days | once fever subsides, a lacy(شريطي) diffuse blanching macular body rash appears that spares the face
80
Children with roseola can develop
Febrile seizures
81
HHV-8 causes
Kaposi sarcoma
82
AIDS and immunosuppression associated with
Kaposi sarcoma
83
Kaposi sarcoma causes
1. dark violaceous( بنفسجي اللون) plaques or nodules on the nose, extremities, and mucous membranes 2. proliferation of vasculture (desregulation of VEG-F)
84
Kaposi sarcoma lesions can be found in
GIT but more commonly on hard palate
85
HHV-8 can also infect B cells and cause
B cell lymphoma (primary effusion lymphoma)
86
Kaposi sarcoma have Higher incidence in
Russian men and African populations
87
Kaposi sarcoma can be confused with
bacillary angiomatosis from B. henselae
88
Poxviruses make their own
Envelope
89
The only DNA virus that replicates in the cytoplasm and has own RNA polymerase is
Pox virus
90
Pox virus diagnosis
``` Guarnieri bodies(inclusion bodies) found in infected cells (intracytoplasmic) ```
91
The largest known DNA virus is
Pox virus
92
Small pox virus lesions
all vesicles are in the ****same stage of development – | synchronous rash – as opposed to the nonsynchronous Varciella chickenpox rash
93
Molluscum contagiosum virus(a member of pox family) causes
flesh colored papule, dome shaped, with central umbilication on the skin
94
Molluscum contagiosum affects
the trunk region in children
95
diffuse Molluscum contagiosum in adults suggest
Suggest HIV infection

Sketchy Micro (3 decks)

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