Vasoconstrictors Flashcards
where does the SNS originate?
Thoracolumbar T1-L2
what converts dopamine to norepinephrine ?
dopamine beta hyroxylase
norepinephrine is metabolized by ___ and ___
MAO and COMT (monamine oxidase and catecholo-methyltranseraese
what are the 4 adrenergic receptors
alpha 1&2, beta 1&2
alpha 1 Is located in the ___
periphery
alpha 2 is located ___
centrally (negative feedback like precedex)
beta-1 is located in the ___
heart
beta-2 is located in the ___
smooth muscle (some beta 2 can be on the heart)
T/F Even though Beta1 and Beta2 share g-protein type mechanism and the end result is increasing cyclic AMP, the end product is different
TRUE . beta1: contraction. beta2: vasodilation
T/F Alpha-1 leads to bronchodilation
FALSE- bronchoconstriction - no good!
Alpha 1 inhibits or promotes insulin secretion?
inhibits
Alpha 1 causes smooth muscle ____
contraction
Alpha 1 receptor is PRE or POST synaptic?
post
Alpha1 causes peripheral vaso____
constriction
what is Alpha 1’s relationship to glucose
stimulates glycogenolysis and gluconeogenesis - by inhibiting insulin, there is more glucose in the blood to use, more ATP, more energy
Alpha 1 effect on pupils?
mydriasis. pupil dilation - open up the eyes more so you can see surroundings
Alpha 1 causes GI contraction or relaxation ?
relaxation
Alpha 2 is pre or post synaptic?
PREsynaptic in the PNS, POSTsynaptic in the CNS
Alpha 2 MOA in PNS
post-synaptic - decreases entry of CA into the cell, limits the release of nor-epi
alpha 2 MOA in the CNS
sedation, decreased sympathetic outflow, decreased BP, platelet aggregation
BETA1 receptor is ____synaptic
POST
what does Beta1 do to HR, conduction velocity, and myocardial contractility ?
Increases.
Beta1–more complete and faster heartbeat to get more blood out into the circulation faster
BETA2 is ____synaptic
post
beta 2 stimulation leads to smooth muscle contraction or relaxation?
relaxation
beta 2 leads to peripheral vasoconstriction or vasodilation?
vasodilation.
think: more of a surface area in the periphery for o2 exchange
T/F Beta 2 receptor decreases BP
TRUE
Beta2 causes broncho____
dilation
Beta 2 ___ insulin secretion, but also ____ glycogenolysis and gluconeogenesis
increases.
seems counter intuitive but does both
Beta 2 ____ GI motility
decreases
The PNS has a ____ origin.
craniosacral (III, V VII, X)
PNS - preganglia near _____
organs of innervation
PNS - postganglia secrete _____
Ach
T/F acetylcholine activates both arms of the ANS
TRUE
acetylcholine participates in a ____ ____ action potential
calcium mediated
Cholinergic receptors can be ___ or ____
nicotinic, muscarinic
SNS affects on urinary bladder: smooth muscle ____, sphincter ____
relaxation, contraction
SNS affects on urinary bladder: smooth muscle ____, sphincter ____
contraction, relaxation
SNS cause bronchial smooth muscle ___, while PNS causes bronchial smooth muscle ____
relaxation, contraction
SNS stim causes gallbladder ____, while PNS causes ____
relaxation, contraction
PNS affects on GI tract - motility and sphincter
increases motility, secretion, sphincter relaxation