antiarrhythmics Flashcards
what do class 1 drugs do
inhibit fast sodium channels
IA drug examples
quinidine, procainamide, disopyramide, moricizine
IB drug examples
lidocaine, mexilitine
IC drug examples
flecainide, propafenone
what do class II drugs do
decrease rate of depolarization
example of class II drugs
Beta blockers
what do class III drugs do?
inhibit potassium ion channels
examples of class III drugs
amiodarone and sotalol
what do class IV drugs do
inhibit slow calcium chanels
Class IV drug examples
diltiazem and verapamil
which drug has the active metabolite NAPA
procainamide. increases risk of s/e, QT prolongatoin
T/F: All the 1A’s (procainamide, quinidine, disopyramide) are used for ventricular arrhythmias only.
FALSE. both atrial and ventricular
which drug is a potent CYP2D6 inhibitor as well as a PGP inhibitors leading to multiple drug interactions?
Quinidine
which drug is used in combination with dextromethophan to form Nuedexta?
quinidine
T/F All the 1A’s (procainamide, quinidine, disopyramide) have the side effect of QT prolongation
TRUE
which drug do you see SLE like syndrome with chronic administration?
Procainamide
T/F Lidocaine is effective against supra ventricular arrhythmias
False. it is ineffective, and can make them worse
T/F Lidocaine, as a 1B, blocks sodium channels.
TRUE
what is Lidocaine’s effect on QT interval?
it has very little effect
Which drug is indicated for ventricular arrhythmias, particularly re-entry dysrhythmias
Lidocaine
which drug used to be used for Digoxin toxicity?
phenytoin. it suppresses ventricular dysrhythmias associated with dig tox
T/F Phenytoin, as a 1B, blocks potassium channels.
FALSE. 1B’s block sodium channels
Rapid administration of phenytoin can result in….?
resp arrest, severe hOtn, ventricular ectopy, death
CNS:drowsniess, nystagmus, nausea, vertigo
T/F Flecanidie, as a 1C, blocks Na, K, and Ca channels.
TRUE
T/F Flecainide has little pro-arryhtmic properties
FALSE - very significant arrhythmias
which drug should you avoid in someone who has CAD, LV failure, VT due to its negative iontropic effects?
Flecainide
which drug prolongs QRS?
flecainide
which drug suppresses the SA node, similar to a CCB or BB?
Flecainide
T/F: Recent studies have shown that in A-fib treatment, slowing the rate with BB vs controlling the rhythm with Amio has shown no difference in morbidity and mortality.
TRUE.
more side effects with amio.
