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Pharm Vasoactive Peptides > Vasoactive Peptides Chp 17 > Flashcards

Vasoactive Peptides Chp 17 Flashcards

1
Q

example of angiotensin receptor antagonist

A

Valsartan, Eprosartan, Irbesartan

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2
Q

Valsartan Mechanism of Action

A

Selective Competitive antagonist of angiotensin AT1 receptors

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3
Q

Effects of Valsartan

A

Anteriolar dilation, decreased aldosterone secretion, increase NA+ and water excretion

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4
Q

Uses of Valsartan

A

HTN

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5
Q

Example of Angiotensin Receptor Agonists

A

Angiotensin ll & Compound 21

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6
Q

Mechanism of action for Angiotensin ll

A

AT1 (and AT2) receptor agonist

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7
Q

Effects of Angiotensin ll

A

Increases BP

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8
Q

Uses for Angiotensin ll

A

Vasodilatory Shock

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9
Q

What are some Converting enzyme Inhibitors

A

Enalapril & Captopril

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10
Q

Mechanism of action of Enalapril

A

Inhibits conversion of Angiotensin l to Angiotensin ll

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11
Q

Effects oof Enalapril

A

Arteriolar dilation, decreased aldosterone secretion, increased Na+ and water excretion

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12
Q

Renin Inhibitor

A

Aliskiren

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13
Q

Mechanism of action of Aliskiren

A

Inhibits catalytic activity of Renin

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14
Q

Effects of Aliskiren/Renin Inhibitor

A

Arteriolar dilation, decresed aldosterone secretion, increased Na+ and water excretion

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15
Q

Uses of Renin Inhibitors

A

HTN

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16
Q

Kinin Inhibitors

A

Icatibant, Ecallantide (plasma), Cinryze (decreased bradykinin formation-hereditary angioedema)

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17
Q

Mechanism of action of Kinin Inhibitors

A

Selective antagonists of kinin Beta2 receptors

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18
Q

Effects of Kinin Inhibitors

A

Blocks effect of kinins on pain, hyperalgesia, and inflammation

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19
Q

Examples of Vasopressin agonists

A

Arginine vasopressin, Selepressin & Terlipressin (more selective for V1A receptor

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20
Q

Mechanism of action for Vasopressin Agonist/ Arginine vasopressin

A

Agonist of vasopressin V1 (and V2) receptors

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21
Q

Effects of Vasopressin Agonist

A

Vasoconstriction

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22
Q

Usage of Vasopressin Agonist

A

Vasodilatory Shock

23
Q

What are Vasopressin Antagonists

A

Conivaptan, Relcovaptan (V1), Tolvaptan (V2)

24
Q

Vasopressin Antagonist Action

A

Antagonist of Vasopressin V1 and V2 receptors

25
Effects of Vasopressin Antagonist
Vasodilation
26
Usage of Vasopressin Antagonist
HTN and HF, Hyponatremia
27
Examples of Natriuretic Peptide Agonists
Nesiritide, Vosoritide
28
Mechanism of action of Natriuretic Peptide Agonists
Agonist on receptor sites, agonists of Ctype NPR
29
Effects of NPA
Increases Na+ and water excretion, vasodilation; increased endochondral ossification
30
Usage of NPA
Acute HTN and HF; Achondroplasia
31
Substance P Antagonists
Aprepitant & Fosaprepitant (prodrug)
32
Mechanism of action of Substance P Antagonists
Selective antagonist of tachykinin NK1 receptors
33
Effects of Substance P Antagonists
Blocks several CNS effects of Substance P
34
Usage of Substance P Antagonist
Prevention of chemotherapy-induced N/V
35
Formation of ANG ll
Enzymatic cleavage of ANG l fron ANG by renin, conversion of ANG l to ANG ll by converting enzyme and degradation of ANG ll by several peptidases
36
Renin release in controlled by
Macula Densa in response to Na+ concentration in distal tubules and decreased stretch in baroreceptors, and norepi stimulation
37
Angiotensinogen in synthesized in
The Liver
38
Role of ACE
converts ANG l to ANG ll and inactivated Bradykinin
39
How do ACE inhibitors work
decrease BP without increasing HR and promote natriuresis
40
ACE inhibitors inhibit...
Degradation of bradykinin, substance P, and enkephalins
41
Excess Bradykinin
Causes cough and angioedema
42
Plasma prekallikrein activated by
coagulation factor Xll (FXlla)
43
4 classic symptoms of inflammation
Redness, local heat, swelling, and pain
44
How many vasopressin receptors?
3 and all are G-protein coupled (V1a, V1b, and V2)
45
V1a
Vasoconstriction
46
V1b
mediate release of ACTH
47
V2
mediate antidiuretic action
48
ANP is derived from
cardiac cells and ventricular myocardium
49
ET-1
secreted by vascular endothelium
50
ET-2
produced in the kidneys and intestines
51
ET-3
brain, but also present in GIT, lungs and kidneys
52
Where are the ET-A receptors found
smooth muscle (vasoconstrict)
53
Where are ET-B receptors found
vascular endothelial cells, where they mediate release of PGI-2 and nitric oxide

Pharm Vasoactive Peptides (4 decks)

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