NO-Chp 19 Flashcards
1
Q
What deactivates NO
A
metals, oxygen, and reactive oxygen species
2
Q
Endogenous NO
A
vasodilation, platelet inhibition, immune regulation, NT
3
Q
Exogenous NO
A
Donors; release NO or related NO species; organic nitrated(nitroglycerine) & sodium nitropruisside
4
Q
NO in infants
A
hypoxic resp. failure, reducing pulm. artery resistance and pressure and improved perfusion
5
Q
NO adults
A
for pulm. HTN, acute hypoxemia, and cardiopulm. resusitation
6
Q
Phosphodiesterase inhibitors
A
terminate effects pf NO, which breakdown cGMP to GMP; allows cGMP to persist longer and accumulate (Sildenafil)
7
Q
Effects of NO
A
decrease BP, vasodilator, antithrombotic effects
8
Q
DM and NO
A
endothelial cells are dysfunctional and produce less NO, results in abnormal platelet function and thrombosis
