Vasculopathies

Question 1

Polyarteritis Nodosa

Answer 1

Necrotizing arteritis of medium sized vessels.

Causes vasculitic neuropathy, heart, brain issues

Question 2

Polyarteritis nodosa is associated w/

Answer 2

Hepatitis B

Question 3

Polyarteritis nodosa S/S

Answer 3

Constitutional Sx
Pain with eating
N/V

Question 4

Polyarteritis nodosa skin sx

Answer 4

livedo reticularis
subq nodules
skin ulcers

Question 5

Polyarteritis nodosa Tx

Answer 5

High dose steroids

Cyclophosphamide for severe dz

Question 6

Kawasaki’s Dz

Answer 6

Severe medium sized vessel dz of children (under 5)

Asian males > females

Question 7

Kawasakis Dx

Answer 7

Fever
BIlateral conjunctivitis
Strawberry tongue
Injected pharynx
Body rash
Erythema, swelling of lips, hands and feet

Question 8

Kawasaki labs

Answer 8

ELevated WBC
Thrombocytosis (700,000)
ESR, CRP elevated

Question 9

Kawasaki Tx

Answer 9

IVIG

ASA

Question 10

Wegener’s Granulomatosis

Answer 10

Rare disorder of small arteries Mainly in resp tract, kidneys
4th and 5th decase

Question 11

Wegeners S/S

Answer 11

Develops over 4-12 mo
Pesent w/ upper or lower resp or both
Constitutional sx
Saddle nose deformity

Question 12

Wegeners labs

Answer 12

C-ANCA is specific

Chest CT shows lung changes

Question 13

Wegeners Tx

Answer 13

Corticosteroids
Methotrexate
Cyclophosphamide

Question 14

Henoch-Schonlein Purpura (HSP)

Answer 14

Most common vasculitis in children, but also occurs in adults.

Question 15

HSP S/S

Answer 15

`Palpable purpura (lower extremities)
Abd pain w/ bleed
Arthritis (knees and ankles)
Hematuria or proteinuria (glomerulonephritis)

Question 16

HSP Tx

Answer 16

Usually self limiting over 1-6 weeks.