SLE

Question 1

WHich type of hypersensitivity is SLE?

Answer 1

Type 3, immune complex

Question 2

Lupus epidemiology

Answer 2

500/1 million
women 9:1
20-40
blacks, native americans

Question 3

Lupus Risks

Answer 3

Influenced by HLA-DR3
and 
UV light
Infections
Drugs
Sex Hormones

Question 4

Which drugs cause lupus like syndrome?

Answer 4

Procainamide
Hydralazine
Methyldopa
Quinidine
INH

Question 5

Lupus Patho

Answer 5

B-lymphocyte hyperactivity w/ exaggerated ab production.
Complexes deposit along basement membrane
Localized inflammation
Insidious or acute
Exacerbations and remissions

Question 6

What rash is on the face in lupus?

Answer 6

Malar rash (butterfly)

Question 7

Lupus Nephritis

Answer 7

Occurs in 50%
Glomerulonephritis
Nephrotic Syndrome
HTN
Chronic renal failure

Question 8

Ocular features of SLE

Answer 8

Conjunctivitis
Photophobia
Monocular blindness
Blurred vision
Cotton wool spots

Question 9

SLE Musculoskeletal

Answer 9

Transient symmetrical polyarthritis
Osteonecrosis of hips
Fibromyalgia

Question 10

SLE Pulmonary

Answer 10

Transient basilar pneumonic infiltrates (lupus pneumonitis)
Pleural effusions
Pleuritis
Restrictive lung dz

Question 11

SLE cardiac

Answer 11

Pericarditis
Myocarditis (arrhythmias)
Increased enzymes
Libman sacks endocarditis

Question 12

SLE vascular

Answer 12

Raynauds
A or V thrombosis
Vasculitis
Livedo reticularis

Question 13

SLE GI

Answer 13

Transient, nonspecific abd pain
Primary biliary cirrhosis
Ischemic bowel

Question 14

SLE CNS

Answer 14

Confusion, memory problems
Seizures
Severe HA's
Stroke
Neuropsychq

Question 15

Best test to rule out Lupus?

Answer 15

ANA

Question 16

Alopecia

Answer 16

Hair loss

Question 17

Lupus tx

Answer 17

Glucocorticoids
Antimalarials
Immunosuppressants
IVIG

Question 18

Discoid Lupus

Answer 18

Chronic cutaneous lupus
Plaque like lesions of head, scalp and neck
Genetic component

Question 19

Which antibody is specific for SLE?

Answer 19

Sm