Day 1

Question 1

Class I MHC

Answer 1

Recognition of endogenous antigens

Question 2

Class II MHC

Answer 2

Recognition of exogenous antigens

Question 3

Class II MHC

Answer 3

involved in Complement system

Question 4

B cells form?

Answer 4

Plasma cells that secrete immunoglobulin

Question 5

CD8 = which MHC class?

Answer 5

Class 1

Question 6

CD8 is which type of T cell?

Answer 6

Cytotoxic

Question 7

CD4 cell = which MHC class?

Answer 7

Class II

Question 8

CD4 is which type of T cell?

Answer 8

Helper T cell

Question 9

Anergy

Answer 9

State of immunologic tolerance to Ag

Question 10

ESR

Answer 10

Erythrocyte Sedimentation Rate
Increase w/ age and in women
Elevated in obesity

Question 11

Which 2 conditions is ESR useful for?

Answer 11

Polymyalgia rheumatica (>40)
Giant Cell Arteritis (>90)

Question 12

CRP

Answer 12

C-reactive protein
Acute phase protein made by liver.
DIrect measure of reactants

Question 13

RF

Answer 13

Rheumatoid Factor

80% sensitivity in RA pts

Question 14

RF has lots of false?

Answer 14

Positives

Patient must have high pre-test probability for best diagnostic value

Question 15

Anti-CCP

Answer 15

Citrulline Antibody
Associated w/ RA
Greater specificity

Question 16

ANA

Answer 16

Anti-nuclear antibodies
Indicate systemic autoimmune dz
Sensitive for SLE, but also many other diseases

Question 17

Anti-dsDNA

Answer 17

Specific for SLE

60-70%

Question 18

Anti-Sm

Answer 18

Highly specific for SLE

Question 19

ACA

Answer 19

Anti-centromere antibody

Associated w/ CREST and scleroderma

Question 20

Anti-topoisomerase

Answer 20

Associated w/ diffuse scleroderma

Question 21

Anti-Ro and La

Answer 21

Associated w/ sjogrens

Question 22

Anti-U1 snRNP

Answer 22

Nonspecific

Part of criteria for mixed connective tissue dz

Question 23

Anti-Jo-1

Answer 23

Specific for myositis with interstitial lung dz.

Raynauds

Question 24

Low C3 and C4

Answer 24

Seen in active SLE

Question 25

ANCA

Answer 25

Vasculitis

Question 26

HLA B27 disorders

Answer 26

``` Ankylosing Spondylitis (90%) Reactive arthritis (Reiters, 80%) Enteropathic Spondylitis (75%) Psoriatic Spondylitis (50%) ```

Question 27

Uric Acid

Answer 27

Gout

Question 28

CREST Syndrome

Answer 28

``` Calcinosis Raynaud's syndrome Esophageal dysmotility Sclerodactyly Telangiectasia ```

Question 29

CREST syndrome antibodies

Answer 29

ANA | Anti-centromere Ab

Question 30

Scleroderma tests

Answer 30

Eosinophilia (100%) | ANA

Question 31

Bamboo spine =

Answer 31

ankylosing spondylitis