Vasculitis and CTD

Question 1

3 large vessel vasculitis types

Answer 1

Giant cell
Polymyalgia rheumatica
Takayasu arteritis

Question 2

2 medium vessel vasculitis types

Answer 2

polyarteritis nodosa

kawasaki disease

Question 3

3 small vessel vasculitis types

Answer 3

EGWP
GWP
Microscopic polyangitis

Question 4

4 general symptoms of vasculitis

Answer 4

Fatigue
Anorexia
Weight loss
Fever

Question 5

2 neurological conditions causes by vasculitis

Answer 5

neuropathy

stroke

Question 6

which small vessel vasculitis is associated with c-ANCA?

Answer 6

granulomatosis with polyangiitis.

Question 7

c-ANCA AB target what?

Answer 7

PR3 in cytoplasm

Question 8

which small vessel vasculitis associated with p-ANCA?

Answer 8

Eosinophilic granulomatosis with polyangiitis and microscopic polyangitis

Question 9

3 characteristics of EGWP

Answer 9

Asthma
Eosinophilia
Multiorgan involvement

Question 10

Treatment of small vessel vasculitis to lead to remission

Answer 10

IV cyclophosphamide/ rituximab and glucocorticoid

Question 11

what should be added if vital organ / life threatening?

Answer 11

plasma exchange

Question 12

maintenance therapy for small vessel vasculitis?

Answer 12

Methotrexate / azathioprine / rituximab

& taper GC

Question 13

4 things

to check before starting high dose steroid

Answer 13

gastro protection
bone protection
screen for diabetes
monitor BP / weight

Question 14

3 characteristics of anti-phospholipid syndrome

Answer 14

Recurrent vascular thrombosis
Fetal loss
Thrombocytopenia

Question 15

APS can be secondary to?

Answer 15

SLE

Question 16

2 main AB in APS?

Answer 16

Lupus anticoagulant

Anticardiolipin

Question 17

3 drugs that can induce SLE?

Answer 17

Minocycline, oral contraceptive and hydralazine

Question 18

SLE - autoantibody production against..?

Answer 18

nuclear material

Question 19

SLE type of arthritis..?

Answer 19

non erosive

Question 20

4 dermatological features of SLE

Answer 20

photosensitivity
butterfly rash
hair loss
mucosal ulceration

Question 21

Non infective endocarditis in SLE

Answer 21

Libman-sacks endocarditis

Question 22

3 CV manifestations of SLE

Answer 22

Pericarditis
Myocarditis
Raynaud phenomenon

Question 23

3 pulmonary manifestations of SLE

Answer 23

Pleurisy
Pleural effusions
Pneumonitis

Question 24

Commonest cause of lupus related death

Answer 24

Glomerulonephritis

Question 25

4 haematological manifestations of SLE

Answer 25

lymphopenia
neutropenia
anaemia
antiphosphalipid syndrome

Question 26

Main serological test for SLE

Answer 26

ANA

Question 27

SLE and sjrogens syndrome AB

Answer 27

Anti Ro and La

Question 28

treatment of mild SLE

Answer 28

NSAIDS / hydroxychloroquinine

Question 29

treatment of moderate SLE

Answer 29

corticosteroids / azathiprine / methotrexate

Question 30

treatment of severe SLE

Answer 30

Corticosteroids + cyclphosphamide / tacrolimus

Question 31

which AB can cross the placenta in pregancy?

Answer 31

Anti Ro and La

Question 32

First line for Raynaud’s syndrome

Answer 32

Nifedipine

Question 33

Libman-sacks is ?

Answer 33

endocarditis in the mitral valve - non infective in those with SLE