Methotrexate

Question 1

What cellular function does methotrexate prevent?

Answer 1

Cellular replication

Question 2

Main side effects of methotrexate

Answer 2

Mucosal damage - ulcers and GI upset

Bone marrow suppression

Question 3

3 hypersensitivity reactions in methotrexate

Answer 3

Rashes, hepatitis or pneumonitis

Question 4

Long term use of methotrexate can cause (2)

Answer 4

Hepatic cirrhosis or pulmonary fibrosis

Question 5

Contraception advice w/ methotrexate

Answer 5

Men and women need to take contraception whilst using and 3m after - teratogenic

Question 6

methotrexate contraindicated in?

Answer 6

Severe renal impairment

Question 7

methotrexate avoided in?

Answer 7

Impaired liver function

Question 8

How often is methotrexate taken?

Answer 8

Once a week

Question 9

What should be given alongside methotrexate ?

Answer 9

Folic acid

Question 10

When should they seek medical advice when taking methotrexate ?

Answer 10

Sore throat / fever
Bruising or bleeding
Abdopain / dark urine
SOB