Vasculitis

Question 1

2 examples of large vessel vasculitis

Answer 1

Giant Cell Arteritis

Takayasu’s Arteritis

Question 2

2 examples of medium vessel vasculitis

Answer 2

Polyarteritis Nodosa

Kawasaki Disease

Question 3

2 examples of pANCA +ve small vessel vasculitis

Answer 3

Churg-Strauss

Microscopic Polyangiitis

Question 4

An example of cANCA small vessel vasculitis

Answer 4

Wegener’s Granulomatosis (granulomatosis with polyangiitis)

Question 5

2 examples of ANCA -ve small vessel vasculitis

Answer 5

Henoch-Schonlein Purpura
Goodpasture’s disease
Cryoglobulinaemia
Cutaneous Leukocytoclastic Vasculitis

Question 6

What disease is GCA associated with?

Answer 6

Polymyalgia Rheumatica in 50%

Question 7

What medication would you give for GCA?

Answer 7

40-60g prednisolone

Question 8

Pain and stiffness in shoulders, neck and hips
Subacute onset
Worse in the morning
No weakness
Fatigue, fever and weight loss

Answer 8

Polymyalgia Rheumatica

Question 9

What are the features of Takayasu’s arteritis?

Answer 9

Constitutional symptoms
Absent unilateral pulses in upper extremities
Unequal BP
May present symptoms of upper limb claudication

Question 10

Who is most likely to have Takayasu’s arteritis

Answer 10

Japanese girls aged 20-40

Question 11

What disease is polyarteritis nodosa associated with

Answer 11

Hep B

Question 12

What is the pathophysiology of Wegener’s

Answer 12

Necrotising granulomatous inflammation and small vessel vasculitis

Question 13

What are the URT features of Wegener’s

Answer 13

Chronic sinusitis
Epistaxis
Saddle nose

Question 14

What are the LRT features of Wegener’s

Answer 14

Cough
Haemoptysis
Pleuritis

Question 15

What would you find on urine dip in a patient with Wegener’s

Answer 15

Haematuria and proteinuria

Question 16

What are the features of Churg-Strauss

Answer 16

Late-onset asthma
Eosinophilia
Palpable purpura and petechiae

Question 17

What antibody is associated with Goodpasture’s

Answer 17

Anti-GBM antibodies