Autoimmune Connective Tissue Disease Flashcards
Which diseases have RF antibodies
Sjogren’s - 100%
Felty’s - 100%
RA - 70%
Which diseases have ANA antibodies
SLE - >95%
Autoimmune hepatitis - 75%
Sjogren’s - 70%
Which disease has dsDNA antibodies
SLE
What antibody is associated with CREST
Anti-centromere
What antibodies are associated with Diffuse Systemic Sclerosis
Anti-Scl70 and Anti-RNA pol 1/2/3
What antibodies are associated with SLE
Anti-dsDNA, Anti-Ro, Anti-La, Anti-Sm, Anti-RNP
What antibodies are associated with Sjogren’s
RF, Anti-Ro, Anti-La
Patient has floppy ears, saddle-nose deformity and stridor
Relapsing polychondritis - causes tenderness, inflammation and destruction of cartilage
What diseases are associated with Relapsing Polychondritis
Aortic valve disease
Polyarthritis
Vasculitis
What are the common features of Behcet’s Syndrome
Recurrent oral and genital ulceration
Anterior/posterior uveitis
Erythema nodosum
Who is most likely to present with primary Sjogren’s
Women aged 30-50
What diseases can cause secondary Sjogren’s
RA
SLE
Systemic sclerosis
What diseases is Sjogren’s associated with
Thyroid disease, Autoimmune hepatitis, Primary biliary cirrhosis, Marginal zone MALT lymphoma
What can cause secondary Raynaud’s
Systemic sclerosis, SLE, RA, Sjogren’s, thrombocytosis, beta blockers
What is the colour change in Raynaud’s
White to blue to crimson
