vasculitis Flashcards
pathogenesis of vasculitis
ICs
Cā
necrosis and thrombosis
large vessel vasculitis symptoms
limb claudication asymmetric BP absence of pulses bruits aortic dilation
medium vasculitis symptoms
cutaneous nodules ulcers arthritis livedo reticularis digital gangrene mononeuritis multiplex microaneurysms
small vessel vasculitis symptoms
purpura urticaria glomerulonephritis alveolar hemorrhage arthritis granulomas splinter hemorrhages uveitis
large cell vasculitities
Takaysu arteritis (TAK) Giant cell arteritis (GCA)
medium vessel vasculitis
polyarteritis nodosa (PAN) Kawasaki disease (KD) Buergers disease
small vessel ANCA assocaited
microscopic polyangitis (MPA)
granulomatosis with polyangitis (Wegengers)
eosinophilic granulomatosis with polyangitis (Churg strauss)
small vessel IC associated
anti-GBM (goodpastures)
cryoglobulinemic vasculitis (CV)
IgA vasculitis (Henoch-Schonlein and IgAV)
hypocomplimentemic urticarial vasculitis
vasculitis associated with systemic disease
SLE
rheumatoid vasculitis
sarcoid vasculitis
vasculitis associated with infections
Hep B, C
syphilis
CA
other vasculitities
drug induced either ICs or ANCA
Takayasus arteritis
aka pulseless disease
10 btwn arms
brutis
takaysus arteriogram
dilation, aneurysm or narrowing in aorta or main brr
Giant cell (temporal) arteritis
age >50
new cephalgia, jaw claudication, arm claudication, visual disurbances, neck pain, abdominal pain
polymyalgia rhematica
type of giant cell arteritis
stiffness and pain in shoulders and hips (NOT weakness)
giant cell arteritis tests
elevated ESR
increased AlkP
abnormal aa Bx (multinucleated giant cells)
CT, MRI, PET scans -> vascular edema and intimal thickening
if temporal Bx is normal
must do MRI or CT angio for subclavian or axillary vessel narrowing
skip lesions- so might be missed
if you see wrist or foot drop should think what?
this is mononeuritis multiplex
medium vessel vasculitis
polyarteritis nodosa
fever wt loss livedo reticularis, skin ulcers, nodules lungs spared testicular pain or tenderness myalgias mono or poly neuropaty may have heart or brain involvement
kawasaki disease
kids fever for 5+days strawberry tongue erythematous rash- cheeks, palms, soles, cervical adenopathy conjunctivitis
hypocomplementemic urticarial vasculitis aka
anti-C1q vascultitis
hypocomplementemic urticarial vasculitis associated with
SLE
hypocomplementemic urticarial vasculitis symptoms
wheals for >24 hours followed by ecchymosis
what is essential mixed cryoglobulinemia associated with
hep C
sjogrens
