Skin DSA Flashcards

1
Q

skin fnxs

A
barrier
tactile interaction
body temp regulation
sexual attractiveness
immune system
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2
Q

skin immune fnx

A

cytokines and defensin production

Ag presentation via langerhans cells and dermal dendrocytes

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3
Q

layers of skin

A

epidermis
dermis (papillary and reticular)
subQ

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4
Q

adnexae

A

3 major structural units and specialized nn structures:

  • pilar units
  • eccrine units
  • apocrine units
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5
Q

pilar units

A

hair units

pilosebaceous units and errector pili mm

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6
Q

eccrine units

A

eecrine glands and ducts

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7
Q

apocrine units

A

apocrine glands and ducts

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8
Q

layers of epi

A
stratum corneum
stratum lucindum
statum granulosum 
stratum spinosum
stratum basalis
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9
Q

stratum corneum

A

corneocytes (final step in differentiation of keratinocytes differentiation)
thickest in palms and soles

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10
Q

stratum lucindum

A

only in palms and soles

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11
Q

stratum granulosum

A

keratinocytes lose their nuclei and cytoplasm appearing granular

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12
Q

stratum spinosum

A

keratinocytes become connected via desmosomes and produce lamellar bodies
langerhan cells are in this layer

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13
Q

basal/germinal layer

A

proliferating and non-proliferating keratinocytes attached to BM by hemidesmosomes
merkel cells here

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14
Q

apocrine glands

A

present deep in dermis

often at jnx of reticular dermis and subQ

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15
Q

melanocytes

A

each melanocyte will supplly about 30 keratinocytes with melanosomes

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16
Q

papillary dermis

A

finely woven type I collagen
some type III collagen and network of elastic fiber
healing by secondary intention
capillaries of superficial plexus

17
Q

Basement membrane

A

defines invasion of carcinoma

contains proteins of blistering immune diseases

18
Q

blistering immune diseases

A

bullous pemphigoid
dermatitis herpetiformis
epidermolysis bullosa

19
Q

inflammatory conditions of BM

A

discoid lupus erythmatosus

20
Q

lammellar/lamellated/pacinian corpuscle

A

encapsulated nn ending
pressure receptor
found in deep dermis or hypodermis

21
Q

meissner/tactile corpuscles/papillae

A

touch receptor
confined to dermal papillae
most numerous in hand and feet

22
Q

general skin nn supply

A

free nn endings detect pain and temp

innervation by sympathetic nervous system controls blood flow and hair movement

23
Q

SubQ/hypodermis

A

loose and dense CT
adipocytes in lobules
large number of blood vessels (deep vascular plexus)
connects reticular dermis with fascia of underlying tissue

24
Q

deep vascular plexus

A

sends perpendicular small aa to traverse the reticular dermis and supply blood to superficial vascular plexus in dermal papillae

25
Q

subQ fnxs

A

body temp regulation
primary depot for fat storage
major skin layer where aging becomes apparent dt loss of adipose tissue

26
Q

intrinsic aging changes

A

aberrant basal layer proliferation (increased risk of CA)
decrease in melanocytes: UV damage
decrease in langerhans cells
thinning: decrease in ground substance cells and adnexae, stiffer collagen and elastic fibers

27
Q

decrease hair shaft diameter

A

by age 70 loose 25-50% of cross sectional diameter present in young people

28
Q

solar elastosis

A

actininc degeneration of reticular dermis collagen

telangiectastias

29
Q

sunburn

A

acute injury caused by mid-UV radiation
changes in dermis: increased blood flow, superficial vessels show endothelial swelling, perivenular edema, mixed perivascular inflammatory infiltrate