Vasculitis

Question 1

2 Differences in Takayasu Arteritis from Temporal (giant cell) Arteritis

Answer 1

<50 yo (usually young Asian females)

More proximal, usually off aortic arch vessels so get weak or absent pulse in upper extremity

Question 2

Polyarteritis Nodosa (what it is, important omission, serum association, hallmark appearance)

Answer 2

Necrotizing vasculitis of multiple organs (melena and shit)
Spares lungs
Associated w/ serum HBsAg
Get “string of pearls” from fibrosis healing and aneurysms in b/w

Question 3

Kawasaki Disease Super Important Point

Answer 3

Involves coronary arteries, so can get MI or aneurysm, so the ONLY time you treat a child w/ viral sx with aspirin (comes in with nonspecific viral symptoms and rash on soles/palms) bc risk of Reye’s

Question 4

Buerger Disease

Answer 4

Smoking disease of necrotizing/gangrene in digits

Question 5

Wegener Granulomatosis (what it affects, serum marker, tx)

Answer 5

Involves nasopharynx (sinusitis/ulceration), lungs (bilateral nodular infiltrates), and kidney (hematuria due to rapidly progressive glomerulonephritis)
c-ANCA
CYCLOPHOSPHAMIDE and steroids, relapses are common

Question 6

3 Differences in Microscopic Polyangitis from Wegener Granulomatosis

Answer 6

Nasopharyngeal involvement absent
Granulomas absent
p-ANCA instead of c-ANCA

Question 7

3 Differences in Churg-Strauss from Microscopic Polyangitis

Answer 7

Granulomatous
Eosinophila (in inflammation and peripherally)
Asthma

Question 8

Henoch-Schonlein Purpura

Answer 8

Palpable purpura on buttocks and legs from IgA activation usually following URI. Also causes IgA nephropathy

Question 9

c-ANCA Small Vessel Vasculitis and 2 p-ANCA

Answer 9

c-ANCA: Wegener’s

p-ANCA: Microscopic Polyangitis and Churg-Strauss